タンパク質結晶化・構造解析サービス FastLane™ Premium Target List
結晶構造解析 FastLane™ Premium ターゲットリスト
結晶化用タンパク質がスタンバイ済みですので、化合物をご送付頂きますとすぐに共結晶化条件検討に取り掛かります。
化合物受領後、2~8週間で解析結果をお届けいたします。
Kinases |
BTK |
Tyrosine-protein kinase BTK |
CDK2 |
Cyclin-dependent kinase 2 |
CK2 |
Casein kinase II subunit alpha |
CLK3 |
Dual specificity protein kinase CLK3 |
DAPK3 (ZIP, ZIPK ) |
Death-associated protein kinase 3 |
DYRK1A |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (a.a. 127-485) |
EphA7 |
Ephrin type-A receptor 7 kinase |
MAP2K4 (JNKK1, MEK4, MKK4) |
Dual specificity mitogen-activated protein kinase kinase 4 |
LATS2 |
Large tumor suppressor, homolog 2 (Drosophila) |
PIK3C3 (Vps34) |
Phosphatidylinositol 3-kinase catalytic subunit type 3 |
PFKFB3 |
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 |
PIM1 |
Pim-1 oncogene |
PIM3 |
Pim-3 oncogene |
PIP4K2A (PIP5K2A) |
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha |
PLK4 (STK18) |
Serine/threonine-protein kinase |
RSK1 |
Ribosomal protein S6 kinase |
STK10 (LOK) |
LOK or Serine/threonine-protein kinase 10 |
STK17A(DRAK1) |
DRAK1 or Serine/threonine-protein kinase 17A |
STK17B (DRAK2) |
DRAK2 or Serine/threonine-protein kinase 17B |
Epigenetics |
ATAD2A |
Bromodomain, ATPase family AAA domain-containing protein 2 (a.a. 981-1108) |
ATAD2B |
Bromodomain, ATPase family AAA domain-containing protein 2B, (a.a. 952-1086) |
JMJD2C (KDM4C) |
KDM4C or Lysine-specific demethylase 4C (a.a. 1-347) |
SMARCA2B |
bromodomain of human BRM |
SMARCA4 |
Bromodomain, Transcription activator BRG1 |
Proteases |
Cathepsin C (DPPI) |
DPPI or Dipeptidyl peptidase 1 |
DPP4 |
Dipeptidyl peptidase 4 |
Thrombin |
human alpha thrombin |
USP7 |
Ubiquitin specific peptidase 7 |
USP8 |
Ubiquitin carboxyl-terminal hydrolase 8 |
USP21 |
Ubiquitin carboxyl-terminal hydrolase 21 |
Others |
Aldose reductase (AR) |
AR or Aldose reductase (a.a. 1-316) |
BCAT2 |
Branched-chain-amino-acid aminotransferase, mitochondrial |
Beta-lactamase (BlaC) |
BlaC or Beta-lactamase (M. tuberculosis) |
Bfl-1 |
Bcl-2-related protein A1 |
BSSL |
Bile salt-stimulated lipase |
cGAS |
Cyclic GMP-AMP synthase |
CYP51A1 |
Lanosterol 14-alpha demethylase |
DHODH |
Dihydroorotate dehydrogenase (human) |
DNA GyraseB |
Type II topoisomerase |
eIF4E |
Eukaryotic translation initiation factor 4E |
Gal-3C |
Galectin-3 carbohydrate recognition domain |
Gal-8N |
Galectin-8 |
GART |
Trifunctional purine biosynthetic protein adenosine-3 |
GMPR2 |
GMP reductase 2 |
HSP90 |
Heat shock protein HSP 90-alpha |
IL-17A |
IInterleukin-17A |
LDHA |
L-lactate dehydrogenase A chain (rabbit) |
LeuT |
Na(+):neurotransmitter symporter, Snf family (Aquifex aeolicus VF5) |
NRP1 |
Neuropilin-1 |
PDE4D |
cAMP-specific 3', 5'-cyclic phosphodiesterase 4D |
PSD-95 |
Postsynaptic density protein 95 |
PTP1B (PTPN1) |
PTPN1 or Tyrosine-protein phosphatase non-receptor type 1 |
ROR-gamma |
Nuclear receptor ROR-gamma |
S100A4 (Mts 1) |
Mts1 or Protein S100-A4 |
S100A9 (MRP14) |
MRP14 or Protein S100-A9 |
S100A12 |
Protein S100-A12 |
SHP2(PTPN11) |
Src homology region 2 domain-containing phosphatase 2 |
Tubulin |
Pig tubulin alpha-1A |
Ubiquitin |
Ubiquitin-60S ribosomal protein L40 |
mAb targets |
CD47 |
Cluster of Differentiation 47 |
CD137 |
Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), 4-1BB |
CD142 (tissue factor) |
Platelet tissue factor, factor III |
GPVI |
Glycoprotein VI |
HER2 (ERBB2) |
Receptor tyrosine-protein kinase erbB-2 |
IL-8 |
Interleukin-23 |
IL-23 |
Interleukin-23 |
SARS CoV-2 RBD |
severe acute respiratory syndrome coronavirus-2 receptor-binding domain |
SARS CoV-2 RBD beta |
Spike glycoprotein receptor-binding domain, B.1.351 variant (SARS-CoV-2) |
TIM-3 |
Hepatitis A virus cellular receptor 2 |
TNF-alpha |
Tumor necrosis factor alfa |
- SARomics社について
- スウェーデンのLund市にある最先端のバイオテッククラスター内に2006年生物物理学分野で実績と経験を積んだ研究者たちにより創設され、各メンバーの技術力の高さとチームワークの良さを強みとし精力的に活動している企業です。積み重ねられ続ける結晶化構造解析成功数が彼らの実力を示しており、彼らが持ち備える生物物理学分野の知識と技術を最大限に駆使し世界中の創薬をサポートしています。近隣に立地するMAX IV最新シンクロトロン施設、彼らが長年かけて築いてきた幅広いアカデミアとのネットワーク等も彼ら支援事業に優位性を与えています。
- http://saromics.com/