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- タンパク質結晶化・構造解析サービス
- FastLane™ Standard Target List
タンパク質結晶化・構造解析サービス FastLane™ Standard Target List
結晶構造解析 FastLane™ Standard ターゲットリスト
タンパク質製造準備が整った状態でお客様の化合物を受領し確立されたプロトコールにそってタンパク質製造の後、迅速に結晶化・構造解析を試みます。
化合物受領後、4～12週間で解析結果をお届けいたします。
| Kinases | |
|---|---|
| AK1 | Adenylate kinase isoenzyme 1 (a.a. 1-193) |
| AK2 | Adenylate kinase isoenzyme 2, mitochondrial (a.a. 1-239) |
| AK3L1 | Adenylate kinase isoenzyme 4, mitochondrial (a.a. 1-223) |
| AK5 | Adenylate kinase isoenzyme 5 (a.a. 366-562) |
| BMPR2 | Bone morphogenetic protein receptor type-2 (a.a. 189-517) |
| CAMK1D (CaMK1δ) | Calcium/calmodulin-dependent protein kinase type 1D (a.a. 1-333) |
| CAMK1G (CaMK1γ) | Calcium/calmodulin-dependent protein kinase type 1G (a.a. 18-316) |
| CAMK2A (CaMK2α) | Calcium/calmodulin-dependent protein kinase type II subunit alpha (a.a. 13-302) |
| CAMK2B (CaMK2β) | Calcium/calmodulin-dependent protein kinase type II subunit beta (a.a. 11-303) |
| CAMK2D (CaMK2δ) | Calcium/calmodulin-dependent protein kinase type II subunit delta (a.a. 11-309) |
| CAMK2G (CaMK2γ) | Calcium/calmodulin-dependent protein kinase type II subunit gamma (a.a. 5-315) |
| CAMK4 | Calcium/calmodulin-dependent protein kinase type IV (a.a. 15-340) |
| CLK1 | Dual specificity protein kinase CLK1 (a.a. 148-484) |
| CLK2 | Dual specificity protein kinase CLK2 (a.a. 135-496) |
| CLK3 | Dual specificity protein kinase CLK3 (a.a. 284-638) |
| CSNK1G1 (CK1γ1) | Casein kinase I isoform gamma-1 (a.a. 45-352) |
| CSNK1G2 (CK1γ2) | Casein kinase I isoform gamma-2 (a.a. 43-353) |
| CSNK1G3 (CK1γ3) | Casein kinase I isoform gamma-3 (a.a. 35-362) |
| DMPK | Myotonin-protein kinase (a.a. 11-420) |
| DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 (a.a. 146-552) |
| FLT1 (VEGFR1) | VEGFR1 or Tyrosine-protein kinase receptor FLT (a.a. 801-1158) |
| GAK | Cyclin-G-associated kinase (a.a. 12-347) |
| Haspin (GSG2) | GSG2 or Serine/threonine-protein kinase haspin (a.a. 465-798) |
| ITPK1 | Inositol-tetrakisphosphate 1-kinase (a.a. 1-327) |
| ITPKC | Inositol-trisphosphate 3-kinase C (a.a. 425-683) |
| MAP2K6 (MAPKK6, MEK6) | Dual specificity mitogen-activated protein kinase kinase 6 (a.a. 47-334) |
| MAP3K5 (ASK1, MEKK5) | Mitogen-activated protein kinase kinase kinase 5 (MAPK/ERK kinase kinase 5), (a.a. 659-951) |
| MAPK11 (p38β) | Mitogen-activated protein kinase 11 (p38b), (a.a. 5-350) |
| MAPK6 (ERK3) | Mitogen-activated protein kinase 6 (a.a. 9-327) |
| MPSK1 (STK16) | STK16 or Serine/threonine-protein kinase 16 (a.a. 13-305) |
| MST4 | Serine/threonine-protein kinase (a.a. 1-300) |
| NEK2 (NEK2A, NLK1) | Serine/threonine-protein kinase (a.a. 1-271) |
| PAK4 | Serine/threonine-protein kinase PAK 4 (a.a. 291-591) |
| PAK5 (PAK7) | PAK7 or Serine/threonine-protein kinase PAK 7 (a.a. 425-719) |
| PAK6 | Serine/threonine-protein kinase PAK 6 (a.a. 383-681) |
| PCTK1 (PCTAIRE1(CDK16)／CycY) | Cyclin-dependent kinase 16 (a.a. 163-478) |
| PHKG2 | Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (a.a. 6-293) |
| PIP5K2C (PIP4K2C) | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (a.a. 32-421) |
| PKM2 | Pyruvate kinase isozymes (a.a. 3-530) |
| PKMYT1 | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (a.a. 75-362) |
| PTK2B (PYK2) | Protein-tyrosine kinase 2-beta (a.a. 414-692) |
| SLK | STE20-like serine/threonine-protein kinase (a.a. 19-320) |
| SRPK2 | SRSF protein kinase 2 (a.a. 51-688) |
| TTK | Dual specificity protein kinase TTK (a.a. 519-808) |
| VRK1 | Serine/threonine-protein kinase (a.a. 3-364) |
| VRK2 | Serine/threonine-protein kinase (a.a. 14-335) |
| VRK3 | Inactive serine/threonine-protein kinase VRK3 (a.a. 146-474) |
| YSK1 (STK25) | STK25 or Serine/threonine kinase 25 (a.a. 1-293) |
| Phosphatases | |
|---|---|
| DUSP13 | Dual specificity protein phosphatase 13 isoform B (a.a. 1-198) |
| IMPA2 | Inositol monophosphatase 2 (a.a. 16-288) |
| INPP5B | Type II inositol 1,4,5-trisphosphate 5-phosphatase (a.a. 339-643) |
| INPP5E | 72 kDa inositol polyphosphate 5-phosphatase (a.a. 275-623) |
| INPPL1 | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (a.a. 419-732) |
| ITPA | Inosine triphosphate pyrophosphatase (a.a. 1-194) |
| LHPP | Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (a.a. 1-270) |
| MDP1 | Magnesium-dependent phosphatase 1 (a.a. 1-165) |
| MTMR6 | Myotubularin-related protein 6 (a.a. 1-505) |
| NANP | N-acylneuraminate-9-phosphatase (a.a. 1-248) |
| PHPT1 | 14 kDa phosphohistidine phosphatase (a.a. 5-125) |
| PTPN3 | Non-receptor tyrosine-protein phosphatase type 3 (a.a. 628-913) |
| PTPN4 | Non-receptor tyrosine-protein phosphatase type 4 (a.a. 611-926). |
| PTPN5 | Non-receptor tyrosine-protein phosphatase type 5 (a.a. 282-563) |
| PTPN7 | Non-receptor tyrosine-protein phosphatase type 7 (a.a. 65-358) |
| PTPN9 (MEG2) | (MEG2), Non-receptor tyrosine-protein phosphatase type 9 (a.a. 277-582) |
| PTPN11 | Non-receptor tyrosine-protein phosphatase type 11 (a.a. 237-533) |
| PTPN14 | Non-receptor tyrosine-protein phosphatase type 14 (a.a. 886-1187) |
| PTPN18 | Non-receptor tyrosine-protein phosphatase type 18 (a.a. 6-299) |
| PTPN22 | Non-receptor tyrosine-protein phosphatase type 22 (a.a. 1-302) |
| PTPRB | Receptor-type tyrosine-protein phosphatase beta (a.a. 1686-1971) |
| PTPRE | Receptor-type tyrosine-protein phosphatase epsilon (a.a. 107-697) |
| PTPRG | Receptor-type tyrosine-protein phosphatase epsilon (a.a. 827-1445) |
| PTPRJ | Receptor-type tyrosine-protein phosphatase eta (a.a. 1019-1311) |
| PTPRK | Receptor-type tyrosine-protein phosphatase eta (a.a. 865-1154) |
| PTPRN2 | Receptor-type tyrosine-protein phosphatase N2 (a.a. 715-1010). |
| PTPRO | Receptor-type tyrosine-protein phosphatase O (a.a. 916-1208) |
| PTPRR | Receptor-type tyrosine-protein phosphatase R (a.a. 375-655). |
| PTPRT | Receptor-type tyrosine-protein phosphatase T (a.a. 868-1151) |
| RNGTT | mRNA-capping enzyme (a.a. 1-219) |
| THTPA | Thiamine-triphosphatase (a.a. 1-215) |
| Epigenetic : bromodomains | |
|---|---|
| ASH1L | Bromodomain, Histone-lysine N-methyltransferase ASH1L (a.a. 2438-2561) |
| BAZ2B | Bromodomain adjacent to zinc finger domain protein 2B (a.a. 2054-2168) |
| BPTF | Bromodomain, Nucleosome-remodeling factor subunit BPTF (a.a. 2914-3037) |
| BRD1 | Bromodomain-containing protein 1 (a.a. 556-688) |
| BRD9 | Bromodomain-containing protein 9 (a.a. 134-239) |
| BRWD1 | Bromodomain and WD repeat-containing protein 1 (a.a. 1310-1430 Bromodomain 2) |
| CECR2 | Bromodomain, Cat eye syndrome critical region protein 2 (a.a. 424-538) |
| CREBBP | Bromodomain, CREB-binding protein (a.a. 1081-1197) |
| EP300 | Bromodomain, Histone acetyltransferase p300, (a.a. 1040-1161) |
| KAT2A | Bromodomain, Histone acetyltransferase KAT2A, (a.a. 729-837). |
| KAT2B | Bromodomain, Histone acetyltransferase KAT2B (a.a. 715-831) |
| PBRM1 | Bromodomain, Protein polybromo-1 (a.a. 43-156). |
| PBRM1 | Bromodomain, Protein polybromo-1 (a.a. 178-291). |
| PBRM1 | Bromodomain, Protein polybromo-1 (a.a. 388-494) |
| PBRM1 | Bromodomain, Protein polybromo-1 (a.a. 645-766) |
| PBRM1 | Bromodomain, Protein polybromo-1 (a.a. 773-917) |
| PHIP | Bromodomain, PH-interacting protein (a.a. 1302-1434 Bromodomain 2) |
| TAF1 | Bromodomain, Transcription initiation factor TFIID subunit 1 (a.a. 1373-1635, Bromodomains 1 & 2). |
| TAF1 | Bromodomain, Transcription initiation factor TFIID subunit 1 (a.a. 1501-1635 Bromodomain 2) |
| TAF1L | Bromodomain, Transcription initiation factor TFIID subunit 1-like (a.a. 1523-1654) |
| Epigenetic Demethlases & Others | |
|---|---|
| JMJD2A (KDM4A) | JMJD2A - Lysine-specific demethylase 4A (a.a. 1-359). |
| JMJD2B (KDM4B) | JMJD2B - KDM4B or Lysine-specific demethylase 4B (a.a. 1-346). |
| JMJD2C (KDM4C) | JMJD2C - KDM4C or Lysine-specific demethylase 4C (a.a. 875-995 tudor domains). |
| JMJD2D (KDM4D) | JMJD2D - KDM4D or Lysine-specific demethylase 4C (a.a. 12-341). |
| JMJD3 (KDM6B) | JMJD3 - Lysine-specific demethylase 6B (a.a.1176-1502). |
| JMJD6 | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (a.a. 1-335) |
| KDM4E (KDM4DL) | KDM4DL or Lysine-specific demethylase 4E (a.a. 1-336) |
| MINA | Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA (a.a. 26-465) |
| PHF8 | Histone lysine demethylase PHF8 (a.a. 115-483) |
| PARP2 | Poly [ADP-ribose] polymerase 2 (a.a. 235-579). |
| PARP3 | Poly [ADP-ribose] polymerase 3 (a.a. 178-532) |
| PARP10 | Poly [ADP-ribose] polymerase 10 (a.a. 809-1017) |
| PARP12 | Poly [ADP-ribose] polymerase 12 (a.a. 489-684) |
| PARP14 | Poly [ADP-ribose] polymerase 14 (a.a. 1611-1801) |
| PARP15 | Poly [ADP-ribose] polymerase 15 (a.a. 459-656) |
| TNKS | Tankyrase-1 (a.a. 1091-1325) |
| TNKS2 | Tankyrase-2 (a.a. 946-1152) |
| ZC3HAV1 | Zinc finger CCCH-type antiviral protein 1 (a.a. 724-896) |
| Other targets | |
|---|---|
| ARNT | Aryl hydrocarbon receptor nuclear translocator (a.a. 356-470) |
| BAK1 | Bcl-2 homologous antagonist/killer, mitochondrial apoptosis regulator (a.a. 21-190) |
| BCL2A1 | Bcl-2-related protein A1 (a.a. 1-149) |
| EPAS1 (Hif2a) | Hif2a or Endothelial PAS domain-containing protein 1 (a.a. 239-350) |
| GLS | Glutaminase kidney isoform, mitochondrial (a.a. 221-533) |
| MMP12 | Matrix metalloproteinase-12 |
| MTH1 (NUDT1 or 7) | NUDT1 or 7,8-dihydro-8-oxoguanine triphosphatase (a.a. 42-197). |
| NT5C2 | Cytosolic purine 5'-nucleotidase (a.a. 1-536) |
| NT5C3 | Cytosolic 5'-nucleotidase 3A (a.a. 64-336) |
| NUDT3 | Diphosphoinositol polyphosphate phosphohydrolase 1 (a.a. 1-172) |
| NUDT6 | Nucleoside diphosphate-linked moiety X motif 6 (a.a. 141-316) |
| NUDT10 | Diphosphoinositol polyphosphate phosphohydrolase 3-alpha (a.a. 17-144) |
| NUDT14 | Uridine diphosphate glucose pyrophosphatase (a.a. 28-222) |
| NUDT16 | U8 snoRNA-decapping enzyme (a.a. aa1-aa195) |
| NUDT16L1 | Protein syndesmos (a.a. 6-211) |
| NUDT18 | 8-oxo-dGDP phosphatase NUDT18 (a.a. 26-179) |
| NUDT21 | Cleavage and polyadenylation specificity factor subunit 5 (a.a. 21-227) |
| PHGDH | D-3-phosphoglycerate dehydrogenase (a.a. 4-314) |
| PSAT1 | Phosphoserine aminotransferase (a.a. 17-370) |
| PPARG | Peroxisome proliferator-activated receptor gamma (a.a. 232-505) |
| PYCR1 | Pyrroline-5-carboxylate reductase 1, mitochondrial (a.a. 1-300) |
| THEM2 | Acyl-coenzyme A thioesterase 13 (a.a. 19-140) |
| USP2 | Ubiquitin carboxyl-terminal hydrolase 2 (a.a. 258-605) |
| USP5 | Ubiquitin carboxyl-terminal hydrolase 5 (a.a. 163-291) |
- SARomics社について
- スウェーデンのLund市にある最先端のバイオテッククラスター内に2006年生物物理学分野で実績と経験を積んだ研究者たちにより創設され、各メンバーの技術力の高さとチームワークの良さを強みとし精力的に活動している企業です。積み重ねられ続ける結晶化構造解析成功数が彼らの実力を示しており、彼らが持ち備える生物物理学分野の知識と技術を最大限に駆使し世界中の創薬をサポートしています。近隣に立地するMAX IV最新シンクロトロン施設、彼らが長年かけて築いてきた幅広いアカデミアとのネットワーク等も彼ら支援事業に優位性を与えています。
- http://saromics.com/
