CDK19(CDC2L6)／CycC

GST-CDK19

M

A

P

I

L

G

Y

W

K

I

K

G

L

V

Q

P

T

R

L

L

L

E

Y

L

E

E

K

Y

E

E

H

L

Y

E

R

D

E

G

D

K

W

R

N

K

K

F

E

L

G

L

E

F

P

N

L

P

Y

Y

I

D

60

NP_055891.1|1|502

GST-CDK19

G

D

V

K

L

T

Q

S

M

A

I

I

R

Y

I

A

D

K

H

N

M

L

G

G

C

P

K

E

R

A

E

I

S

M

L

E

G

A

V

L

D

I

R

Y

G

V

S

R

I

A

Y

S

K

D

F

E

T

L

K

V

120

NP_055891.1|1|502

GST-CDK19

D

F

L

S

K

L

P

E

M

L

K

M

F

E

D

R

L

C

H

K

T

Y

L

N

G

D

H

V

T

H

P

D

F

M

L

Y

D

A

L

D

V

V

L

Y

M

D

P

M

C

L

D

A

F

P

K

L

V

C

F

K

180

NP_055891.1|1|502

GST-CDK19

K

R

I

E

A

I

P

Q

I

D

K

Y

L

K

S

S

K

Y

I

A

W

P

L

Q

G

W

Q

A

T

F

G

G

G

D

H

P

P

K

S

D

L

E

V

L

F

Q

G

P

L

G

A

M

G

S

G

I

Q

R

P

T

240

NP_055891.1|1|502

GST-CDK19

S

T

M

D

Y

D

F

K

A

K

L

A

A

E

R

E

R

V

E

D

L

F

E

Y

E

G

C

K

V

G

R

G

T

Y

G

H

V

Y

K

A

R

R

K

D

G

K

D

E

K

E

Y

A

L

K

Q

I

E

G

T

G

300

NP_055891.1|1|502

M

D

Y

D

F

K

A

K

L

A

A

E

R

E

R

V

E

D

L

F

E

Y

E

G

C

K

V

G

R

G

T

Y

G

H

V

Y

K

A

R

R

K

D

G

K

D

E

K

E

Y

A

L

K

Q

I

E

G

T

G

58

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

GST-CDK19

I

S

M

S

A

C

R

E

I

A

L

L

R

E

L

K

H

P

N

V

I

A

L

Q

K

V

F

L

S

H

S

D

R

K

V

W

L

L

F

D

Y

A

E

H

D

L

W

H

I

I

K

F

H

R

A

S

K

A

N

K

360

NP_055891.1|1|502

I

S

M

S

A

C

R

E

I

A

L

L

R

E

L

K

H

P

N

V

I

A

L

Q

K

V

F

L

S

H

S

D

R

K

V

W

L

L

F

D

Y

A

E

H

D

L

W

H

I

I

K

F

H

R

A

S

K

A

N

K

118

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

GST-CDK19

K

P

M

Q

L

P

R

S

M

V

K

S

L

L

Y

Q

I

L

D

G

I

H

Y

L

H

A

N

W

V

L

H

R

D

L

K

P

A

N

I

L

V

M

G

E

G

P

E

R

G

R

V

K

I

A

D

M

G

F

A

R

420

NP_055891.1|1|502

K

P

M

Q

L

P

R

S

M

V

K

S

L

L

Y

Q

I

L

D

G

I

H

Y

L

H

A

N

W

V

L

H

R

D

L

K

P

A

N

I

L

V

M

G

E

G

P

E

R

G

R

V

K

I

A

D

M

G

F

A

R

178

*

*

*

*

*

*

*

*

*

*

*

*

*

*

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*

*

*

*

*

*

*

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*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

GST-CDK19

L

F

N

S

P

L

K

P

L

A

D

L

D

P

V

V

V

T

F

W

Y

R

A

P

E

L

L

L

G

A

R

H

Y

T

K

A

I

D

I

W

A

I

G

C

I

F

A

E

L

L

T

S

E

P

I

F

H

C

R

Q

480

NP_055891.1|1|502

L

F

N

S

P

L

K

P

L

A

D

L

D

P

V

V

V

T

F

W

Y

R

A

P

E

L

L

L

G

A

R

H

Y

T

K

A

I

D

I

W

A

I

G

C

I

F

A

E

L

L

T

S

E

P

I

F

H

C

R

Q

238

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

GST-CDK19

E

D

I

K

T

S

N

P

F

H

H

D

Q

L

D

R

I

F

S

V

M

G

F

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A

D

K

D

W

E

D

I

R

K

M

P

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Y

P

T

L

Q

K

D

F

R

R

T

T

Y

A

N

S

S

L

I

K

Y

M

E

540

NP_055891.1|1|502

E

D

I

K

T

S

N

P

F

H

H

D

Q

L

D

R

I

F

S

V

M

G

F

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A

D

K

D

W

E

D

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K

M

P

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Y

P

T

L

Q

K

D

F

R

R

T

T

Y

A

N

S

S

L

I

K

Y

M

E

298

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

GST-CDK19

K

H

K

V

K

P

D

S

K

V

F

L

L

L

Q

K

L

L

T

M

D

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I

T

S

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A

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Q

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Y

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D

P

L

P

T

L

D

V

F

A

G

C

Q

I

P

Y

P

K

R

E

F

600

NP_055891.1|1|502

K

H

K

V

K

P

D

S

K

V

F

L

L

L

Q

K

L

L

T

M

D

P

T

K

R

I

T

S

E

Q

A

L

Q

D

P

Y

F

Q

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D

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T

L

D

V

F

A

G

C

Q

I

P

Y

P

K

R

E

F

358

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

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*

*

*

*

*

*

*

*

*

*

*

*

*

*

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*

*

*

GST-CDK19

L

N

E

D

D

P

E

E

K

G

D

K

N

Q

Q

Q

Q

Q

N

Q

H

Q

Q

P

T

A

P

P

Q

Q

A

A

A

P

P

Q

A

P

P

P

Q

Q

N

S

T

Q

T

N

G

T

A

G

G

A

G

A

G

V

G

G

660

NP_055891.1|1|502

L

N

E

D

D

P

E

E

K

G

D

K

N

Q

Q

Q

Q

Q

N

Q

H

Q

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T

A

P

P

Q

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A

A

A

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P

Q

A

P

P

P

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Q

N

S

T

Q

T

N

G

T

A

G

G

A

G

A

G

V

G

G

418

*

*

*

*

*

*

*

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*

*

*

*

*

*

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*

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GST-CDK19

T

G

A

G

L

Q

H

S

Q

D

S

S

L

N

Q

V

P

P

N

K

K

P

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L

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G

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G

G

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D

Y

Q

H

S

S

S

R

L

N

Y

Q

S

S

V

Q

G

S

S

Q

S

Q

720

NP_055891.1|1|502

T

G

A

G

L

Q

H

S

Q

D

S

S

L

N

Q

V

P

P

N

K

K

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S

G

A

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G

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D

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S

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L

N

Y

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S

S

V

Q

G

S

S

Q

S

Q

478

*

*

*

*

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*

*

*

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GST-CDK19

S

T

L

G

Y

S

S

S

S

Q

Q

S

S

Q

Y

H

P

S

H

Q

A

H

R

Y

744

NP_055891.1|1|502

S

T

L

G

Y

S

S

S

S

Q

Q

S

S

Q

Y

H

P

S

H

Q

A

H

R

Y

502

*

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*

*

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*

*

//

GST-CyclinC

M

A

P

I

L

G

Y

W

K

I

K

G

L

V

Q

P

T

R

L

L

L

E

Y

L

E

E

K

Y

E

E

H

L

Y

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R

D

E

G

D

K

W

R

N

K

K

F

E

L

G

L

E

F

P

N

L

P

Y

Y

I

D

60

NP_005181.2|1|283

GST-CyclinC

G

D

V

K

L

T

Q

S

M

A

I

I

R

Y

I

A

D

K

H

N

M

L

G

G

C

P

K

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R

A

E

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S

M

L

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G

A

V

L

D

I

R

Y

G

V

S

R

I

A

Y

S

K

D

F

E

T

L

K

V

120

NP_005181.2|1|283

GST-CyclinC

D

F

L

S

K

L

P

E

M

L

K

M

F

E

D

R

L

C

H

K

T

Y

L

N

G

D

H

V

T

H

P

D

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M

L

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D

A

L

D

V

V

L

Y

M

D

P

M

C

L

D

A

F

P

K

L

V

C

F

K

180

NP_005181.2|1|283

GST-CyclinC

K

R

I

E

A

I

P

Q

I

D

K

Y

L

K

S

S

K

Y

I

A

W

P

L

Q

G

W

Q

A

T

F

G

G

G

D

H

P

P

K

S

D

L

E

V

L

F

Q

G

P

L

G

A

M

G

S

M

A

G

N

F

W

240

NP_005181.2|1|283

M

A

G

N

F

W

6

*

*

*

*

*

*

GST-CyclinC

Q

S

S

H

Y

L

Q

W

I

L

D

K

Q

D

L

L

K

E

R

Q

K

D

L

K

F

L

S

E

E

E

Y

W

K

L

Q

I

F

F

T

N

V

I

Q

A

L

G

E

H

L

K

L

R

Q

Q

V

I

A

T

A

T

300

NP_005181.2|1|283

Q

S

S

H

Y

L

Q

W

I

L

D

K

Q

D

L

L

K

E

R

Q

K

D

L

K

F

L

S

E

E

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Y

W

K

L

Q

I

F

F

T

N

V

I

Q

A

L

G

E

H

L

K

L

R

Q

Q

V

I

A

T

A

T

66

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

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*

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GST-CyclinC

V

Y

F

K

R

F

Y

A

R

Y

S

L

K

S

I

D

P

V

L

M

A

P

T

C

V

F

L

A

S

K

V

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G

V

V

S

N

T

R

L

I

A

A

A

T

S

V

L

K

T

R

F

S

Y

A

F

P

K

360

NP_005181.2|1|283

V

Y

F

K

R

F

Y

A

R

Y

S

L

K

S

I

D

P

V

L

M

A

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K

V

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V

S

N

T

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L

I

A

A

A

T

S

V

L

K

T

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F

S

Y

A

F

P

K

126

*

*

*

*

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GST-CyclinC

E

F

P

Y

R

M

N

H

I

L

E

C

E

F

Y

L

L

E

L

M

D

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L

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M

G

Q

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D

M

L

L

P

L

A

W

R

I

V

N

D

T

Y

R

T

420

NP_005181.2|1|283

E

F

P

Y

R

M

N

H

I

L

E

C

E

F

Y

L

L

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L

M

D

C

C

L

I

V

Y

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P

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P

L

L

Q

Y

V

Q

D

M

G

Q

E

D

M

L

L

P

L

A

W

R

I

V

N

D

T

Y

R

T

186

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

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*

*

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*

GST-CyclinC

D

L

C

L

L

Y

P

P

F

M

I

A

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246

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517

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283

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//