CDK3／CycC

GST-CDK3

M

A

P

I

L

G

Y

W

K

I

K

G

L

V

Q

P

T

R

L

L

L

E

Y

L

E

E

K

Y

E

E

H

L

Y

E

R

D

E

G

D

K

W

R

N

K

K

F

E

L

G

L

E

F

P

N

L

P

Y

Y

I

D

60

NP_001249.1|1|305

GST-CDK3

G

D

V

K

L

T

Q

S

M

A

I

I

R

Y

I

A

D

K

H

N

M

L

G

G

C

P

K

E

R

A

E

I

S

M

L

E

G

A

V

L

D

I

R

Y

G

V

S

R

I

A

Y

S

K

D

F

E

T

L

K

V

120

NP_001249.1|1|305

GST-CDK3

D

F

L

S

K

L

P

E

M

L

K

M

F

E

D

R

L

C

H

K

T

Y

L

N

G

D

H

V

T

H

P

D

F

M

L

Y

D

A

L

D

V

V

L

Y

M

D

P

M

C

L

D

A

F

P

K

L

V

C

F

K

180

NP_001249.1|1|305

GST-CDK3

K

R

I

E

A

I

P

Q

I

D

K

Y

L

K

S

S

K

Y

I

A

W

P

L

Q

G

W

Q

A

T

F

G

G

G

D

H

P

P

K

S

D

L

E

V

L

F

Q

G

P

L

G

A

M

G

S

M

D

M

F

Q

K

240

NP_001249.1|1|305

M

D

M

F

Q

K

6

*

*

*

*

*

*

GST-CDK3

V

E

K

I

G

E

G

T

Y

G

V

V

Y

K

A

K

N

R

E

T

G

Q

L

V

A

L

K

K

I

R

L

D

L

E

M

E

G

V

P

S

T

A

I

R

E

I

S

L

L

K

E

L

K

H

P

N

I

V

R

L

300

NP_001249.1|1|305

V

E

K

I

G

E

G

T

Y

G

V

V

Y

K

A

K

N

R

E

T

G

Q

L

V

A

L

K

K

I

R

L

D

L

E

M

E

G

V

P

S

T

A

I

R

E

I

S

L

L

K

E

L

K

H

P

N

I

V

R

L

66

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

GST-CDK3

L

D

V

V

H

N

E

R

K

L

Y

L

V

F

E

F

L

S

Q

D

L

K

K

Y

M

D

S

T

P

G

S

E

L

P

L

H

L

I

K

S

Y

L

F

Q

L

L

Q

G

V

S

F

C

H

S

H

R

V

I

H

R

360

NP_001249.1|1|305

L

D

V

V

H

N

E

R

K

L

Y

L

V

F

E

F

L

S

Q

D

L

K

K

Y

M

D

S

T

P

G

S

E

L

P

L

H

L

I

K

S

Y

L

F

Q

L

L

Q

G

V

S

F

C

H

S

H

R

V

I

H

R

126

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

GST-CDK3

D

L

K

P

Q

N

L

L

I

N

E

L

G

A

I

K

L

A

D

F

G

L

A

R

A

F

G

V

P

L

R

T

Y

T

H

E

V

V

T

L

W

Y

R

A

P

E

I

L

L

G

S

K

F

Y

T

T

A

V

D

I

420

NP_001249.1|1|305

D

L

K

P

Q

N

L

L

I

N

E

L

G

A

I

K

L

A

D

F

G

L

A

R

A

F

G

V

P

L

R

T

Y

T

H

E

V

V

T

L

W

Y

R

A

P

E

I

L

L

G

S

K

F

Y

T

T

A

V

D

I

186

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

GST-CDK3

W

S

I

G

C

I

F

A

E

M

V

T

R

K

A

L

F

P

G

D

S

E

I

D

Q

L

F

R

I

F

R

M

L

G

T

P

S

E

D

T

W

P

G

V

T

Q

L

P

D

Y

K

G

S

F

P

K

W

T

R

K

480

NP_001249.1|1|305

W

S

I

G

C

I

F

A

E

M

V

T

R

K

A

L

F

P

G

D

S

E

I

D

Q

L

F

R

I

F

R

M

L

G

T

P

S

E

D

T

W

P

G

V

T

Q

L

P

D

Y

K

G

S

F

P

K

W

T

R

K

246

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

GST-CDK3

G

L

E

E

I

V

P

N

L

E

P

E

G

R

D

L

L

M

Q

L

L

Q

Y

D

P

S

Q

R

I

T

A

K

T

A

L

A

H

P

Y

F

S

S

P

E

P

S

P

A

A

R

Q

Y

V

L

Q

R

F

R

H

539

NP_001249.1|1|305

G

L

E

E

I

V

P

N

L

E

P

E

G

R

D

L

L

M

Q

L

L

Q

Y

D

P

S

Q

R

I

T

A

K

T

A

L

A

H

P

Y

F

S

S

P

E

P

S

P

A

A

R

Q

Y

V

L

Q

R

F

R

H

305

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

//

His-CCNC(CyclinC)

M

S

Y

Y

H

H

H

H

H

H

D

Y

D

I

P

T

T

E

N

L

Y

F

Q

G

A

M

G

S

M

A

G

N

F

W

Q

S

S

H

Y

L

Q

W

I

L

D

K

Q

D

L

L

K

E

R

Q

K

D

L

K

F

L

60

NP_005181.2|1|283

M

A

G

N

F

W

Q

S

S

H

Y

L

Q

W

I

L

D

K

Q

D

L

L

K

E

R

Q

K

D

L

K

F

L

32

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

His-CCNC(CyclinC)

S

E

E

E

Y

W

K

L

Q

I

F

F

T

N

V

I

Q

A

L

G

E

H

L

K

L

R

Q

Q

V

I

A

T

A

T

V

Y

F

K

R

F

Y

A

R

Y

S

L

K

S

I

D

P

V

L

M

A

P

T

C

V

F

120

NP_005181.2|1|283

S

E

E

E

Y

W

K

L

Q

I

F

F

T

N

V

I

Q

A

L

G

E

H

L

K

L

R

Q

Q

V

I

A

T

A

T

V

Y

F

K

R

F

Y

A

R

Y

S

L

K

S

I

D

P

V

L

M

A

P

T

C

V

F

92

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

His-CCNC(CyclinC)

L

A

S

K

V

E

E

F

G

V

V

S

N

T

R

L

I

A

A

A

T

S

V

L

K

T

R

F

S

Y

A

F

P

K

E

F

P

Y

R

M

N

H

I

L

E

C

E

F

Y

L

L

E

L

M

D

C

C

L

I

V

180

NP_005181.2|1|283

L

A

S

K

V

E

E

F

G

V

V

S

N

T

R

L

I

A

A

A

T

S

V

L

K

T

R

F

S

Y

A

F

P

K

E

F

P

Y

R

M

N

H

I

L

E

C

E

F

Y

L

L

E

L

M

D

C

C

L

I

V

152

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

His-CCNC(CyclinC)

Y

H

P

Y

R

P

L

L

Q

Y

V

Q

D

M

G

Q

E

D

M

L

L

P

L

A

W

R

I

V

N

D

T

Y

R

T

D

L

C

L

L

Y

P

P

F

M

I

A

L

A

C

L

H

V

A

C

V

V

Q

Q

K

D

240

NP_005181.2|1|283

Y

H

P

Y

R

P

L

L

Q

Y

V

Q

D

M

G

Q

E

D

M

L

L

P

L

A

W

R

I

V

N

D

T

Y

R

T

D

L

C

L

L

Y

P

P

F

M

I

A

L

A

C

L

H

V

A

C

V

V

Q

Q

K

D

212

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

His-CCNC(CyclinC)

A

R

Q

W

F

A

E

L

S

V

D

M

E

K

I

L

E

I

I

R

V

I

L

K

L

Y

E

Q

W

K

N

F

D

E

R

K

E

M

A

T

I

L

S

K

M

P

K

P

K

P

P

P

N

S

E

G

E

Q

G

P

300

NP_005181.2|1|283

A

R

Q

W

F

A

E

L

S

V

D

M

E

K

I

L

E

I

I

R

V

I

L

K

L

Y

E

Q

W

K

N

F

D

E

R

K

E

M

A

T

I

L

S

K

M

P

K

P

K

P

P

P

N

S

E

G

E

Q

G

P

272

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

His-CCNC(CyclinC)

N

G

S

Q

N

S

S

Y

S

Q

S

311

NP_005181.2|1|283

N

G

S

Q

N

S

S

Y

S

Q

S

283

*

*

*

*

*

*

*

*

*

*

*

//