CDK4／CycD3

GST-CDK4

M

A

P

I

L

G

Y

W

K

I

K

G

L

V

Q

P

T

R

L

L

L

E

Y

L

E

E

K

Y

E

E

H

L

Y

E

R

D

E

G

D

K

W

R

N

K

K

F

E

L

G

L

E

F

P

N

L

P

Y

Y

I

D

60

NP_000066.1|1|303

GST-CDK4

G

D

V

K

L

T

Q

S

M

A

I

I

R

Y

I

A

D

K

H

N

M

L

G

G

C

P

K

E

R

A

E

I

S

M

L

E

G

A

V

L

D

I

R

Y

G

V

S

R

I

A

Y

S

K

D

F

E

T

L

K

V

120

NP_000066.1|1|303

GST-CDK4

D

F

L

S

K

L

P

E

M

L

K

M

F

E

D

R

L

C

H

K

T

Y

L

N

G

D

H

V

T

H

P

D

F

M

L

Y

D

A

L

D

V

V

L

Y

M

D

P

M

C

L

D

A

F

P

K

L

V

C

F

K

180

NP_000066.1|1|303

GST-CDK4

K

R

I

E

A

I

P

Q

I

D

K

Y

L

K

S

S

K

Y

I

A

W

P

L

Q

G

W

Q

A

T

F

G

G

G

D

H

P

P

K

S

D

L

E

V

L

F

Q

G

P

L

G

A

M

G

S

M

A

T

S

R

Y

240

NP_000066.1|1|303

M

A

T

S

R

Y

6

*

*

*

*

*

*

GST-CDK4

E

P

V

A

E

I

G

V

G

A

Y

G

T

V

Y

K

A

R

D

P

H

S

G

H

F

V

A

L

K

S

V

R

V

P

N

G

G

G

G

G

G

G

L

P

I

S

T

V

R

E

V

A

L

L

R

R

L

E

A

F

300

NP_000066.1|1|303

E

P

V

A

E

I

G

V

G

A

Y

G

T

V

Y

K

A

R

D

P

H

S

G

H

F

V

A

L

K

S

V

R

V

P

N

G

G

G

G

G

G

G

L

P

I

S

T

V

R

E

V

A

L

L

R

R

L

E

A

F

66

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

GST-CDK4

E

H

P

N

V

V

R

L

M

D

V

C

A

T

S

R

T

D

R

E

I

K

V

T

L

V

F

E

H

V

D

Q

D

L

R

T

Y

L

D

K

A

P

P

P

G

L

P

A

E

T

I

K

D

L

M

R

Q

F

L

R

360

NP_000066.1|1|303

E

H

P

N

V

V

R

L

M

D

V

C

A

T

S

R

T

D

R

E

I

K

V

T

L

V

F

E

H

V

D

Q

D

L

R

T

Y

L

D

K

A

P

P

P

G

L

P

A

E

T

I

K

D

L

M

R

Q

F

L

R

126

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

GST-CDK4

G

L

D

F

L

H

A

N

C

I

V

H

R

D

L

K

P

E

N

I

L

V

T

S

G

G

T

V

K

L

A

D

F

G

L

A

R

I

Y

S

Y

Q

M

A

L

T

P

V

V

V

T

L

W

Y

R

A

P

E

V

L

420

NP_000066.1|1|303

G

L

D

F

L

H

A

N

C

I

V

H

R

D

L

K

P

E

N

I

L

V

T

S

G

G

T

V

K

L

A

D

F

G

L

A

R

I

Y

S

Y

Q

M

A

L

T

P

V

V

V

T

L

W

Y

R

A

P

E

V

L

186

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

GST-CDK4

L

Q

S

T

Y

A

T

P

V

D

M

W

S

V

G

C

I

F

A

E

M

F

R

R

K

P

L

F

C

G

N

S

E

A

D

Q

L

G

K

I

F

D

L

I

G

L

P

P

E

D

D

W

P

R

D

V

S

L

P

R

480

NP_000066.1|1|303

L

Q

S

T

Y

A

T

P

V

D

M

W

S

V

G

C

I

F

A

E

M

F

R

R

K

P

L

F

C

G

N

S

E

A

D

Q

L

G

K

I

F

D

L

I

G

L

P

P

E

D

D

W

P

R

D

V

S

L

P

R

246

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

GST-CDK4

G

A

F

P

P

R

G

P

R

P

V

Q

S

V

V

P

E

M

E

E

S

G

A

Q

L

L

L

E

M

L

T

F

N

P

H

K

R

I

S

A

F

R

A

L

Q

H

S

Y

L

H

K

D

E

G

N

P

E

537

NP_000066.1|1|303

G

A

F

P

P

R

G

P

R

P

V

Q

S

V

V

P

E

M

E

E

S

G

A

Q

L

L

L

E

M

L

T

F

N

P

H

K

R

I

S

A

F

R

A

L

Q

H

S

Y

L

H

K

D

E

G

N

P

E

303

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

//

GST-CyclinD3

M

A

P

I

L

G

Y

W

K

I

K

G

L

V

Q

P

T

R

L

L

L

E

Y

L

E

E

K

Y

E

E

H

L

Y

E

R

D

E

G

D

K

W

R

N

K

K

F

E

L

G

L

E

F

P

N

L

P

Y

Y

I

D

60

NP_001751.1|1|292

GST-CyclinD3

G

D

V

K

L

T

Q

S

M

A

I

I

R

Y

I

A

D

K

H

N

M

L

G

G

C

P

K

E

R

A

E

I

S

M

L

E

G

A

V

L

D

I

R

Y

G

V

S

R

I

A

Y

S

K

D

F

E

T

L

K

V

120

NP_001751.1|1|292

GST-CyclinD3

D

F

L

S

K

L

P

E

M

L

K

M

F

E

D

R

L

C

H

K

T

Y

L

N

G

D

H

V

T

H

P

D

F

M

L

Y

D

A

L

D

V

V

L

Y

M

D

P

M

C

L

D

A

F

P

K

L

V

C

F

K

180

NP_001751.1|1|292

GST-CyclinD3

K

R

I

E

A

I

P

Q

I

D

K

Y

L

K

S

S

K

Y

I

A

W

P

L

Q

G

W

Q

A

T

F

G

G

G

D

H

P

P

K

S

D

L

E

V

L

F

Q

G

P

L

G

A

M

G

S

M

E

L

L

C

C

240

NP_001751.1|1|292

M

E

L

L

C

C

6

*

*

*

*

*

*

GST-CyclinD3

E

G

T

R

H

A

P

R

A

G

P

D

P

R

L

L

G

D

Q

R

V

L

Q

S

L

L

R

L

E

E

R

Y

V

P

R

A

S

Y

F

Q

C

V

Q

R

E

I

K

P

H

M

R

K

M

L

A

Y

W

M

L

E

300

NP_001751.1|1|292

E

G

T

R

H

A

P

R

A

G

P

D

P

R

L

L

G

D

Q

R

V

L

Q

S

L

L

R

L

E

E

R

Y

V

P

R

A

S

Y

F

Q

C

V

Q

R

E

I

K

P

H

M

R

K

M

L

A

Y

W

M

L

E

66

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

GST-CyclinD3

V

C

E

E

Q

R

C

E

E

E

V

F

P

L

A

M

N

Y

L

D

R

Y

L

S

C

V

P

T

R

K

A

Q

L

Q

L

L

G

A

V

C

M

L

L

A

S

K

L

R

E

T

T

P

L

T

I

E

K

L

C

I

360

NP_001751.1|1|292

V

C

E

E

Q

R

C

E

E

E

V

F

P

L

A

M

N

Y

L

D

R

Y

L

S

C

V

P

T

R

K

A

Q

L

Q

L

L

G

A

V

C

M

L

L

A

S

K

L

R

E

T

T

P

L

T

I

E

K

L

C

I

126

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

GST-CyclinD3

Y

T

D

H

A

V

S

P

R

Q

L

R

D

W

E

V

L

V

L

G

K

L

K

W

D

L

A

A

V

I

A

H

D

F

L

A

F

I

L

H

R

L

S

L

P

R

D

R

Q

A

L

V

K

K

H

A

Q

T

F

L

420

NP_001751.1|1|292

Y

T

D

H

A

V

S

P

R

Q

L

R

D

W

E

V

L

V

L

G

K

L

K

W

D

L

A

A

V

I

A

H

D

F

L

A

F

I

L

H

R

L

S

L

P

R

D

R

Q

A

L

V

K

K

H

A

Q

T

F

L

186

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

GST-CyclinD3

A

L

C

A

T

D

Y

T

F

A

M

Y

P

P

S

M

I

A

T

G

S

I

G

A

A

V

Q

G

L

G

A

C

S

M

S

G

D

E

L

T

E

L

L

A

G

I

T

G

T

E

V

D

C

L

R

A

C

Q

E

Q

480

NP_001751.1|1|292

A

L

C

A

T

D

Y

T

F

A

M

Y

P

P

S

M

I

A

T

G

S

I

G

A

A

V

Q

G

L

G

A

C

S

M

S

G

D

E

L

T

E

L

L

A

G

I

T

G

T

E

V

D

C

L

R

A

C

Q

E

Q

246

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

GST-CyclinD3

I

E

A

A

L

R

E

S

L

R

E

A

A

Q

T

S

S

S

P

A

P

K

A

P

R

G

S

S

S

Q

G

P

S

Q

T

S

T

P

T

D

V

T

A

I

H

L

526

NP_001751.1|1|292

I

E

A

A

L

R

E

S

L

R

E

A

S

Q

T

S

S

S

P

A

P

K

A

P

R

G

S

S

S

Q

G

P

S

Q

T

S

T

P

T

D

V

T

A

I

H

L

292

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

//