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タンパク質結晶化・構造解析サービス FastLane™ Premium Target List

結晶構造解析 FastLane™ Premium ターゲットリスト

結晶化用タンパク質がスタンバイ済みですので、化合物をご送付頂きますとすぐに共結晶化条件検討に取り掛かります。
化合物受領後、2~8週間で解析結果をお届けいたします。

Kinases
BTK Tyrosine-protein kinase BTK
CDK2 Cyclin-dependent kinase 2
CK2 Casein kinase II subunit alpha
CLK3 Dual specificity protein kinase CLK3
DAPK3 (ZIP, ZIPK ) Death-associated protein kinase 3
DYRK1A Dual specificity tyrosine-phosphorylation-regulated kinase 1A (a.a. 127-485)
EphA7 Ephrin type-A receptor 7 kinase
MAP2K4 (JNKK1, MEK4, MKK4) Dual specificity mitogen-activated protein kinase kinase 4
LATS2 Large tumor suppressor, homolog 2 (Drosophila)
PIK3C3 (Vps34) Phosphatidylinositol 3-kinase catalytic subunit type 3
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
PIM1 Pim-1 oncogene
PIM3 Pim-3 oncogene
PIP4K2A (PIP5K2A) Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
PLK4 (STK18) Serine/threonine-protein kinase
RSK1 Ribosomal protein S6 kinase
STK10 (LOK) LOK or Serine/threonine-protein kinase 10
STK17A(DRAK1) DRAK1 or Serine/threonine-protein kinase 17A
STK17B (DRAK2) DRAK2 or Serine/threonine-protein kinase 17B
Epigenetics
ATAD2A Bromodomain, ATPase family AAA domain-containing protein 2 (a.a. 981-1108)
ATAD2B Bromodomain, ATPase family AAA domain-containing protein 2B, (a.a. 952-1086)
JMJD2C (KDM4C) KDM4C or Lysine-specific demethylase 4C (a.a. 1-347)
SMARCA2B bromodomain of human BRM
SMARCA4 Bromodomain, Transcription activator BRG1
Proteases
Cathepsin C (DPPI) DPPI or Dipeptidyl peptidase 1
DPP4 Dipeptidyl peptidase 4
Thrombin human alpha thrombin
USP7 Ubiquitin specific peptidase 7
USP8 Ubiquitin carboxyl-terminal hydrolase 8
USP21 Ubiquitin carboxyl-terminal hydrolase 21
Others
Aldose reductase (AR) AR or Aldose reductase (a.a. 1-316)
BCAT2 Branched-chain-amino-acid aminotransferase, mitochondrial
Beta-lactamase (BlaC) BlaC or Beta-lactamase (M. tuberculosis)
Bfl-1 Bcl-2-related protein A1
BSSL Bile salt-stimulated lipase
cGAS Cyclic GMP-AMP synthase
CYP51A1 Lanosterol 14-alpha demethylase
DHODH Dihydroorotate dehydrogenase (human)
DNA GyraseB Type II topoisomerase
eIF4E Eukaryotic translation initiation factor 4E
Gal-3C Galectin-3 carbohydrate recognition domain
Gal-8N Galectin-8
GART Trifunctional purine biosynthetic protein adenosine-3
GMPR2 GMP reductase 2
HSP90 Heat shock protein HSP 90-alpha
IL-17A IInterleukin-17A
LDHA L-lactate dehydrogenase A chain (rabbit)
LeuT Na(+):neurotransmitter symporter, Snf family (Aquifex aeolicus VF5)
NRP1 Neuropilin-1
PDE4D cAMP-specific 3', 5'-cyclic phosphodiesterase 4D
PSD-95 Postsynaptic density protein 95
PTP1B (PTPN1) PTPN1 or Tyrosine-protein phosphatase non-receptor type 1
ROR-gamma Nuclear receptor ROR-gamma
S100A4 (Mts 1) Mts1 or Protein S100-A4
S100A9 (MRP14) MRP14 or Protein S100-A9
S100A12 Protein S100-A12
SHP2(PTPN11) Src homology region 2 domain-containing phosphatase 2
Tubulin Pig tubulin alpha-1A
Ubiquitin Ubiquitin-60S ribosomal protein L40
mAb targets
CD47 Cluster of Differentiation 47
CD137 Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), 4-1BB
CD142 (tissue factor) Platelet tissue factor, factor III
GPVI Glycoprotein VI
HER2 (ERBB2) Receptor tyrosine-protein kinase erbB-2
IL-8 Interleukin-23
IL-23 Interleukin-23
SARS CoV-2 RBD severe acute respiratory syndrome coronavirus-2 receptor-binding domain
SARS CoV-2 RBD beta Spike glycoprotein receptor-binding domain, B.1.351 variant (SARS-CoV-2)
TIM-3 Hepatitis A virus cellular receptor 2
TNF-alpha Tumor necrosis factor alfa
SARomics社
SARomics社について
スウェーデンのLund市にある最先端のバイオテッククラスター内に2006年生物物理学分野で実績と経験を積んだ研究者たちにより創設され、各メンバーの技術力の高さとチームワークの良さを強みとし精力的に活動している企業です。積み重ねられ続ける結晶化構造解析成功数が彼らの実力を示しており、彼らが持ち備える生物物理学分野の知識と技術を最大限に駆使し世界中の創薬をサポートしています。近隣に立地するMAX IV最新シンクロトロン施設、彼らが長年かけて築いてきた幅広いアカデミアとのネットワーク等も彼ら支援事業に優位性を与えています。