Carna Biosciences, Inc.

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Protein Substrate Product List

Carna's protein substrates are best used in kinase activity assays. All are developed and produced entirely in-house from gene cloning, expression in E.Coli, and purification, and undergo rigorous quality control. Each is available in various sizes, including bulk production and are delivered to you with a lot specific data sheet. Some are utilized in our Profiling Services, contributing to our high quality data acquisition. Please contact us for more detailed information and inquiry.

Protein Substrates

Protein Substrate Tag Carna Product Name Catalog No. Construct Sequence Accession Number Tag Location Expression System Minimum Purchase Size Reference Data
Cofilin2 GST Cofilin2
00-003 Full-length 1-166(end) NP_068733.1 N-terminal GST E. coli 50ug
EIF2S1 GST EIF2S1
00-006 Full-length 1-315(end) NP_004085.1 N-terminal GST E. coli 50ug
EIF4EBP1 GST EIF4EBP1
00-008 Full-length 1-118(end) NP_004086.1 N-terminal GST E. coli 50ug
Smad1 GST Smad1
00-000 Full-length 1-465(end) NP_005891.1 N-terminal GST E. coli 50ug
Smad3 GST Smad3
00-004 Full-length 1-425(end) NP_005893.1 N-terminal GST E. coli 50ug

Inactive Kinases**

Protein Kinase Tag Carna Product Name Catalog No. Construct Sequence Accession Number Tag Location Expression System Minimum Purchase Size Reference Data
Erk2(MAPK1)[inactive mutant] GST Erk2(MAPK1)[inactive mutant]
04-143-11 Full-length 1-360(end) NP_002736.3 N-terminal GST E. coli 50ug
Erk2(MAPK1)[inactive] GST Erk2(MAPK1)[inactive]
04-143-10 Full-length 1-360(end) NP_002736.3 N-terminal GST E. coli 50ug
Erk5(MAPK7)[inactive mutant] GST Erk5(MAPK7)[inactive mutant]
04-145-11 Catalytic domain 1-398 NP_002740 N-terminal GST Insect (sf21) 50ug
Erk5(MAPK7)[inactive] GST Erk5(MAPK7)[inactive]
04-146-10 Catalytic domain 1-398 NP_002740.2 N-terminal GST E. coli 50ug
IKKα(CHUK)[inactive mutant] BTN BTN-IKKα(CHUK)[inactive mutant]
05-412-11-20N Full-length 1-745(end) NP_001269.3 N-terminal DYKDDDDK Insect (sf21) 10ug
JNK1(MAPK8)[inactive mutant] GST JNK1(MAPK8)[inactive mutant]
04-163-11 Catalytic domain 2-364 NP_620634.1 N-terminal GST E. coli 50ug
JNK1(MAPK8)[inactive] GST JNK1(MAPK8)[inactive]
04-163-10 Catalytic domain 2-364 NP_620634.1 N-terminal GST E. coli 50ug
JNK2(MAPK9)[inactive] GST JNK2(MAPK9)[inactive]
04-164-10 Catalytic domain 1-364 NP_002743.3 N-terminal GST E. coli 50ug
MAP2K1[inactive mutant] GST MAP2K1[inactive mutant]
07-109-11 Full-length 1-393(end) NP_002746.1 N-terminal GST Insect (sf21) 50ug
MAP2K1[inactive] BTN BTN-MAP2K1[inactive]
07-441-10-20N Full-length 1-393(end) NP_002746.1 N-terminal DYKDDDDK Insect (sf21) 10ug
GST MAP2K1[inactive]
07-141-10 Full-length 1-393(end) NP_002746.1 N-terminal GST E. coli 50ug
MAP2K6[inactive mutant] GST MAP2K6[inactive mutant]
07-146-11 Full-length 1-334(end) NP_002749.2 N-terminal GST E. coli 50ug
MAP2K6[inactive] GST MAP2K6[inactive]
07-146-10 Full-length 1-334(end) NP_002749.2 N-terminal GST E. coli 50ug
MAP2K7[inactive mutant] GST MAP2K7[inactive mutant]
07-110-11 Full-length 1-419(end) NP_660186.1 N-terminal GST Insect (sf21) 50ug
MAP2K7[inactive] GST MAP2K7[inactive]
07-147-10 Full-length 1-419(end) NP_660186.1 N-terminal GST E. coli 50ug
p38α(MAPK14)[inactive mutant] GST p38α(MAPK14)[inactive mutant]
04-152-11 Truncated 9-352 NP_620581.1 N-terminal GST E. coli 50ug
p38α(MAPK14)[inactive] BTN BTN-p38α(MAPK14)[inactive]
04-452-10-20N Truncated 9-352 NP_620581.1 N-terminal DYKDDDDK Insect (sf21) 10ug
GST p38α(MAPK14)[inactive]
04-152-10 Truncated 9-352 NP_620581.1 N-terminal GST E. coli 50ug
**Carna' s 'inactive' kinases are confirmed to be less active than our 'active' kinase products, and they can become fully catalytically active following phosphorylation by an upstream kinase. In contrast, our 'inactive mutant' kinases are modified to be catalytically inactive, and as such are unable to phosphorylate substrates despite being phosphorylated by upstream kinases.