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Oncolines™ ~ヒト腫瘍細胞株パネル~ 対象ヒト腫瘍細胞株リスト

セルライン名 ATCC参照番号 変異遺伝子* 組織由来
5637 HTB-9 ERBB2, RB1, TP53 Bladder
769-P CRL-1933 No coding alterations found in 38 cancer driver genes Kidney
786-O CRL-1932 CDKN2A, PTEN, TP53 Kidney
A-172 CRL-1620 CDKN2A, PTEN CNS
A-204 HTB-82 ABL-driven Soft tissue
A375 CRL-1619 BRAF, CDKN2A, CDKN2A Skin
A388 CRL-7905 EGFR, NOTCH1, PIK3CA, TP53 Derived from metastatic site
A-427 HTB-53 CDKN2A, CTNNB1, KRAS Lung
A-498 HTB-44 CDKN2A, SETD2 Kidney
A-549 CCL-185 CDKN2A, KRAS, SMARCA4, STK11 Lung
A-704 HTB-45 PBRM1, TP53 Kidney
ACHN CRL-1611 CDKN2A, PBRM1 Kidney
AN3 CA HTB-111 CCND1, FBXW7, NSD1, PIK3R1, PTEN, SETD2, TP53, ZFHX3 Uterus; endometrium
AsPC-1 CRL-1682 CDKN2A, FBXW7, KRAS, TP53 Pancreas
AU-565 CRL-2351 ERBB2, MYC, SMAD4, TP53 Breast
BT-20 HTB-19 CDKN2A, EGFR, PIK3CA, RB1, SPEN, TP53 Breast
BT-549 HTB-122 PTEN, RB1 Breast
BxPC-3 CRL-1687 BRAF, CDKN2A, EP300, SMAD4, TP53 Pancreas
C-33 A HTB-31 ARID1A, FBXW7, PIK3CA, PTEN, SMARCA4, TP53, ZFHX3 Cervix
CAL 27 CRL-2095 CDKN2A, SMAD4, TP53 Aero-digestive tract
CCF-STTG1 CRL-1718 PTEN CNS
CCRF-CEM CCL-119 CCND1, CDKN2A, FBXW7, KRAS, NRAS, NSD1, PTEN, TP53 Blood
COLO 205 CCL-222 APC, BRAF, SMAD4 Colon
COLO 829 CRL-1974 BRAF, CDKN2A, PTEN Skin
Daoy HTB-186 CDKN2A, NF1, PIK3R1, TP53 CNS
DB CRL-2289 TP53 Blood
DLD-1 CCL-221 APC, EP300, KRAS, NCOR1, PIK3CA, SMARCA4, TP53 Colon
DoTc2 4510 CRL-7920 BRCA2, FAT1, NSD1 Cervix
DU 145 HTB-81 CDKN2A, CREBBP, FAT1, KRAS, RB1, STK11, XIRP2 Prostate
DU4475 HTB-123 APC, BRAF, RB1 Breast
ES-2 CRL-1978 BRAF, CCND1, TP53 Ovary
FaDu HTB-43 CCND1, FAT1, SMAD4, TP53 Aero-digestive tract
G-361 CRL-1424 BRAF, CDKN2A, STK11 Skin
HCT-15 CCL-225 APC, BRCA2, EP300, KRAS, NCOR1, PIK3CA, TP53, ZFHX3 Colon
HCT 116 CCL-247 BRCA2, CDKN2A, CHD4, CTNNB1, EP300, KRAS, NCOR1, NF1, PIK3CA, SMARCA4, XIRP2 Colon
HL-60 CCL-240 CDKN2A, MYC, NRAS Blood
Hs 578T HTB-126 MYC, PIK3R1, TP53 Breast
Hs 746T HTB-135 TP53 Stomach
Hs 766T HTB-134 ARID1A, KRAS, LRP1B, SMAD4 Pancreas
HT CRL-2260 EP300, SPEN, TP53 Blood
HT-1080 CCL-121 CDKN2A, NRAS Connective tissue
HuTu 80 HTB-40 CTNNB1, SMARCA4 Duodenum
J82 HTB-1 ERBB2, PTEN Bladder
JAR HTB-144 No coding alterations found in 38 cancer driver genes Placenta
Jurkat E6.1 TIB-152 APC, ARID1A, CDKN2A, CREBBP, FAT1, FBXW7, PTEN, SMARCA4, TP53 Blood
K-562 CCL-243 ABL-driven, CDKN2A, TP53 Blood
KATO III HTB-103 NOTCH1 Stomach
KG-1 CCL-246 No coding alterations found in 38 cancer driver genes Blood
KLE CRL-1622 CCNE1, FBXW7, KRAS, TP53 Uterus; endometrium
KU812 CRL-2099 ABL-driven, TP53 Blood
LNCaP FGC CRL-1740 ATM, BRCA2, PIK3R1, PTEN, SETD2, XIRP2 Prostate
LoVo CCL-229 APC, ARID1A, FBXW7, KRAS, SPEN Colon
LS 174T CL-188 ARID1A, CTNNB1, KRAS, PBRM1, PIK3CA, ZFHX3 Colon
LS411N CRL-2159 APC, ARID1A, BRAF, EP300, FBXW7, PTEN, TP53, XIRP2 Cecum
MCF7 HTB-22 CDKN2A, EP300, PIK3CA Breast
MeWo HTB-65 CDKN2A, NF1, TP53, XIRP2 Skin
MG-63 CRL-1427 CDKN2A, MYC Bone
MIA PaCa-2 CRL-1420 CDKN2A, KRAS, TP53 Pancreas
MOLT-4 CRL-1582 CDKN2A, CHD4, EP300, NOTCH1, NRAS, PTEN, SMARCA4, TP53 Blood
NCCIT CRL-2073 PTEN, TP53 Testis
NCI-H460 HTB-177 ARID1A, CDKN2A, KRAS, LRP1B, MYC, PIK3CA, STK11 Lung
NCI-H661 HTB-183 CCNE1, TP53 Lung
NCI-H82 HTB-175 MYC Lung
OVCAR-3 HTB-161 CCNE1, LRP1B, TP53 Ovary
PA-1 CRL-1572 NRAS Ovary
PC-3 CRL-1435 MYC, PTEN, TP53 Prostate
PFSK-1 CRL-2060 TP53 CNS
RD CCL-136 NF1, NRAS, TP53 Soft tissue
RKO CRL-2577 ARID1A, BRAF, BRCA2, EP300, FAT1, NCOR1, NF1, NSD1, PIK3CA, ZFHX3 Colon
RL CRL-2261 EP300 Blood
RL95-2 CRL-1671 ARID1A, ATM, BRCA2, EP300, PIK3R1, PTEN, SMARCA4, SPEN, TP53, ZFHX3 Uterus; endometrium
RPMI-7951 HTB-66 BRAF, PTEN, TP53 Skin
RS4-11 CRL-1873 CDKN2A, SMARCA4 Blood
RT4 HTB-2 CDKN2A, SMAD4 Bladder
SHP-77 CRL-2195 KRAS, TP53 Lung
SJCRH30 CRL-2061 TP53 Soft tissue
SK-N-AS CRL-2137 NRAS, TP53, XIRP2 CNS
SK-N-FI CRL-2142 NF1, TP53 CNS
SNU-5 CRL-5973 ARID1A, CDKN2A Stomach
SNU-C2B CCL-250 ERBB2, KRAS, SMARCA4, TP53 Cecum
SR CRL-2262 CDKN2A, ZFHX3 Blood
SU-DHL-1 CRL-2955 CREBBP, TP53 Blood
SU-DHL-6 CRL-2959 CREBBP, EP300, TP53 Blood
SUP-T1 CRL-1942 CDKN2A, CHD4, PBRM1, PIK3CA, TP53 Blood
SW48 CCL-231 BRCA2, CTNNB1, EGFR, EP300, FBXW7, NCOR1, SETD2, ZFHX3 Colon
SW480 CCL-228 APC, KRAS, TP53 Colon
SW620 CCL-227 APC, EP300, KRAS, KRAS, MYC, TP53 Colon
SW626 HTB-78 APC, KRAS, SMAD4 Colon
SW837 CCL-235 APC, FBXW7, KRAS, TP53 Rectum
SW872 HTB-92 BRAF, CDKN2A, PTEN Soft tissue
SW900 HTB-59 CDKN2A, FAT1, KRAS, KRAS, NF1, NSD1, TP53 Lung
SW948 CCL-237 APC, ATM, KRAS, PIK3CA, SMAD4, TP53 Colon
SW982 HTB-93 BRAF, CDKN2A Soft tissue
T24 HTB-4 EP300, FAT1, TP53 Bladder
T98G CRL-1690 CDNK2A, TP53 CNS
TCCSUP HTB-5 ARID1A, PIK3CA, RB1, TP53 Bladder
THP-1 TIB-202 ARID1A, CDKN2A, NRAS, PTEN, TP53 Blood
TT CRL-1803 TP53 Thyroid
U-118 MG HTB-15 CDNK2A, TP53 CNS
U-2 OS HTB-96 LRP1B Bone
U-87 MG HTB-14 CDNK2A, NF1 CNS
VA-ES-BJ CRL-2138 CDNK2A Soft tissue

*頻繁な変異が知られている38の代表がん関連遺伝子。実際のOncolines™ の試験では98遺伝子にて評価を致します。

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