Carna Biosciences, Inc.

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Inactive Kinase Protein List

All of Carna's inactive kinase proteins* are developed and produced entirely in-house from gene cloning, expression in E.Coli and purification, and undergo rigorous quality control. All products are available in various sizes starting from 50μg up to bulk production, and are delivered to you with a lot specific data sheet. In addition to GST-tagged (some HIS and other tagged) products, inactive biotinylated kinases labeled with a single biotin at the N-terminus are available for some kinases. Please contact us for more detailed information and inquiry.

To view an example Product Information Sheet, click Carna Product Name of your interest. Lot specific Product Information Sheets are provided with your order, and can also be provided in advance upon request. Archived data sheets are also available, please contact us.

Inactive Kinases**

Protein Kinase Tag Carna Product Name Catalog No. Construct Sequence Accession Number Tag Location Expression System Minimum Purchase Size Reference Data
Erk2(MAPK1)[inactive mutant] GST Erk2(MAPK1)[inactive mutant]
04-143-11 Full-length 1-360(end) NP_002736.3 N-terminal GST E. coli 50ug
Erk2(MAPK1)[inactive] GST Erk2(MAPK1)[inactive]
04-143-10 Full-length 1-360(end) NP_002736.3 N-terminal GST E. coli 50ug
Erk5(MAPK7)[inactive mutant] GST Erk5(MAPK7)[inactive mutant]
04-145-11 Catalytic domain 1-398 NP_002740 N-terminal GST Insect (sf21) 50ug
Erk5(MAPK7)[inactive] GST Erk5(MAPK7)[inactive]
04-146-10 Catalytic domain 1-398 NP_002740.2 N-terminal GST E. coli 50ug
IKKα(CHUK)[inactive mutant] BTN BTN-IKKα(CHUK)[inactive mutant]
05-412-11-20N Full-length 1-745(end) NP_001269.3 N-terminal DYKDDDDK Insect (sf21) 10ug
JNK1(MAPK8)[inactive mutant] GST JNK1(MAPK8)[inactive mutant]
04-163-11 Catalytic domain 2-364 NP_620634.1 N-terminal GST E. coli 50ug
JNK1(MAPK8)[inactive] GST JNK1(MAPK8)[inactive]
04-163-10 Catalytic domain 2-364 NP_620634.1 N-terminal GST E. coli 50ug
JNK2(MAPK9)[inactive] GST JNK2(MAPK9)[inactive]
04-164-10 Catalytic domain 1-364 NP_002743.3 N-terminal GST E. coli 50ug
MAP2K1[inactive mutant] GST MAP2K1[inactive mutant]
07-109-11 Full-length 1-393(end) NP_002746.1 N-terminal GST Insect (sf21) 50ug
MAP2K1[inactive] BTN BTN-MAP2K1[inactive]
07-441-10-20N Full-length 1-393(end) NP_002746.1 N-terminal DYKDDDDK Insect (sf21) 10ug
GST MAP2K1[inactive]
07-141-10 Full-length 1-393(end) NP_002746.1 N-terminal GST E. coli 50ug
MAP2K6[inactive mutant] GST MAP2K6[inactive mutant]
07-146-11 Full-length 1-334(end) NP_002749.2 N-terminal GST E. coli 50ug
MAP2K6[inactive] GST MAP2K6[inactive]
07-146-10 Full-length 1-334(end) NP_002749.2 N-terminal GST E. coli 50ug
MAP2K7[inactive mutant] GST MAP2K7[inactive mutant]
07-110-11 Full-length 1-419(end) NP_660186.1 N-terminal GST Insect (sf21) 50ug
MAP2K7[inactive] GST MAP2K7[inactive]
07-147-10 Full-length 1-419(end) NP_660186.1 N-terminal GST E. coli 50ug
p38α(MAPK14)[inactive mutant] GST p38α(MAPK14)[inactive mutant]
04-152-11 Truncated 9-352 NP_620581.1 N-terminal GST E. coli 50ug
p38α(MAPK14)[inactive] BTN BTN-p38α(MAPK14)[inactive]
04-452-10-20N Truncated 9-352 NP_620581.1 N-terminal DYKDDDDK Insect (sf21) 10ug
GST p38α(MAPK14)[inactive]
04-152-10 Truncated 9-352 NP_620581.1 N-terminal GST E. coli 50ug
**Carna' s 'inactive' kinases are confirmed to be less active than our 'active' kinase products, and they can become fully catalytically active following phosphorylation by an upstream kinase. In contrast, our 'inactive mutant' kinases are modified to be catalytically inactive, and as such are unable to phosphorylate substrates despite being phosphorylated by upstream kinases.
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