Yuko Asamitsu, Aki Ishiyama, Yui Iwamae, Rina Nagao, Rei Hokari, Masato Iwatsuki, Kazuhiko Otoguro, Masaaki Sawa
2024
The 66th ASH Annual Meeting & Exposition
Preliminary Results from a Phase 1b Study of Non-Covalent Pan-Mutant BTK Inhibitor Docirbrutinib (AS-1763) in Patients with Previously Treated B-Cell Malignancies
Nitin Jain, Catherine C. Coombs, James D'Olimpio, Nirav N. Shah, Jacqueline C. Barrientos, Seung Tae Lee, Andrew Gillis-Smith, Shuo Ma, Shirou Kirita, Masaaki Sawa, Kyoko Miyamoto, Akinori Arimura, William G. Wierda, Varsha Gandhi, Javier Pinilla-lbarz
The 66th ASH Annual Meeting & Exposition
Impact of Docirbrutinib (AS-1763) Treatment in CLL: Preclinical Data and Early Clinical Biomarkers
Kyoko Miyamoto, Robert M. Miller, Christine Voors-Pette, Jart A. F. Oosterhaven, Marieke van den Dobbelsteen, Katsuhiro Mihara, Marian Geldof, Yuji Sato, Naomi Matsuda, Shirou Kirita, Masaaki Sawa, Akinori Arimura
EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
Discovery of HM-279, a novel, potent and orally active inhibitor of ALK5 for cancer immunotherapy
Mai Arai, Mitsuharu Hanada, Haruka Taniguchi, Hideki Moriyama, Hiroshi Ohmoto, Tsuyoshi Inoue, Kazuhito Naka, Masaaki Sawa
S. Yumura, D. Kitagawa, K. Moritsugu, A. Nakayama, T. Shinada, M. Sawa, T. Kinoshita
EHA 2024 Hybrid Congress
Preliminary safety and efficacy results from a Phase 1b study of oral non-covalent BTK inhibitor AS-1763 in patients with previously treated B-cell malignancies
N. Jain, C.C. Coombs, J. D’Olimpio, N. N. Shah, J. Barrientos, S. T. Lee, A. Gillis-Smith, S. Ma, S. Kirita, M. Sawa, K. Miyamoto, A. Arimura, W. G. Wierda, V. Gandhi, J. Pinilla-Ibarz
Trial in Progress: A Phase 1b Study of AS-1763, an Oral, Potent and Selective Noncovalent BTK Inhibitor, in Patients with Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Non-Hodgkin Lymphoma
Nitin Jain, James D’Olimpio, Andrew Gillis-Smith, Seung Tae Lee, Nirav N. Shah, Javier Pinilla-Ibarz, Catherine Coombs, Jacqueline Barrientos, Shuo Ma, Masaaki Sawa, Kyoko Miyamoto, Akinori Arimura, Varsha Gandhi, William G. Wierda
The 65th ASH Annual Meeting & Exposition
Characterization and Preclinical Evaluation of AS-1763, an oral, Potent and Selective Noncovalent BTK inhibitor, in Chronic Lymphocytic Leukemia
M. Tanaka, S. Nakamura, T. Sakaue, T. Yamamoto, M. Maekawa , A. Nishinaka, H. Yasuda, K. Yunoki, Y. Sato, M. Sawa, K. Yoshino, M. Shimazawa, M. Hatano, T. Tokuhisa, S. Higashiyama, H. Hara
AACR Annual Meeting 2023
Discovery of a novel activin receptor-like kinases (ALKs) inhibitor targeting TGF-β signaling pathways
M. Arai, M. Hanada, H. Moriyama, H. Ohmoto, K. Naka, M. Sawa
2022
Biochemical and Biophysical Research Communications
A. Ikeda, M. Tsuyuguchi, D. Kitagawa, M. Sawa, S. Nakamura, I. Nakanishi, T. Kinoshita
AACR Annual Meeting 2022
Safety, pharmacokinetics, and pharmacodynamics of AS-1763, a highly selective, orally bioavailable, non-covalent BTK inhibitor, in healthy volunteers
A. Arimura, K. Miyamoto, M. Velinova, M. van den Dobbelsteen, K. Mihara, R. M. Miller, M. Sawa
AACR Annual Meeting 2022
AS-1763: a highly potent, noncovalent and next generation BTK inhibitor for the treatment of patients with B-cell malignancies having C481S mutation in BTK
W. Kawahata, T. Asami, T. Kiyoi, T. Irie, S. Kashimoto, H. Furuichi, K. Miyamoto, A. Arimura, M. Sawa
Biochemical and Biophysical Research Communications
M. Yoshida, H. Nagao, H. Sugiyama, M. Sawa, T. Kinoshita
2021
第50回日本免疫学会学術集会
Enhancement of anti-tumor effects of anti PD-1 Ab by new Bruton’s Tyrosine Kinase inhibitor through inhibiting immunosuppressive M2 like tumor associated macrophages
R. Imagawa, T. Yaguchi, Y. Katoh, Y. Uno, M. Matsushita, M. Sawa, Y. Kawakami
Acta Crystallographica Section F Structural Biology Communications
K. Onidani, N. Miura, Y. Sugiura, Y. Abe, Y. Watabe, T. Kakuya, T. Mori, S. Yoshimoto, J. Adachi, T. Kiyoi, Y. Kabe, M. Suematsu , T. Tomonaga, T. Shibahara, K. Honda
T. Hirozane, M. Masuda, T. Sugano, T. Sekita, N. Goto, T. Aoyama, T. Sakagami, Y. Uno, H. Moriyama, M. Sawa, N. Asano, M. Nakamura, M. Matsumoto, R. Nakayama, T. Kondo, A. Kawai, E. Kobayashi, T. Yamada
T. Sugano, M. Masuda, F. Takeshita, N. Motoi, T. Hirozane, N. Goto, S. Kashimoto, Y. Uno, H. Moriyama, M. Sawa, Y. Nagakawa, A. Tsuchida, M. Seike, A. Gemma, T. Yamada
T. Sekita, T. Yamada, E. Kobayashi, A. Yoshida, T. Hirozane, A. Kawai, Y. Uno, H. Moriyama, M. Sawa, Y. Nagakawa, A. Tsuchida, M. Matsumoto, M. Nakamura, R. Nakayama, M. Masuda
JCM. Uitdehaag, JJ. Kooijman, JADM. de Roos, MBW. Prinsen, J. Dylus, N. Willemsen-Seegers, Y. Kawase, M. Sawa, J. de Man, SJC. van Gerwen, RC. Buijsman, GJR. Zaman
2018
16th Annual Discovery on Target
Discovery of AS-871, a Selective and Non-Covalent BTK Inhibitor for the Treatment of Rheumatoid Arthritis
Nicole Willemsen-Seegers, Joost C.M. Uitdehaag, Martine B.W. Prinsen, Judith R.F. de Vetter, Jos de Man, Masaaki Sawa, Yusuke Kawase, Rogier C. Buijsman, Guido J.R. Zaman
2016
EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
A Novel TNIK inhibitor, N5355 potently induced apoptotic cell death through down-regulation of Wnt signaling.
EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
Development of high-throughput screening assay to identify inhibitors of diacylglycerol kinases (DGKs): Utilization of DGK assay panel for the selectivity profiling of inhibitors.
Ryoko Nakai, Mariko Hatakeyama, Yu Nishioka, Yasuyuki Kirii, Masaaki Sawa
EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
Compound selectivity and target residence time of kinase inhibitors studied with surface plasmon resonance.
N. Willemsen-Seegers, J. Uitdehaag, M. Prinsen, J. De Vetter, J. De Man, M. Sawa, Y. Kawase, R. Buijsman, G. Zaman
EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
Cell panel profiling of pre-clinical and clinical anti-cancer agents reveals conserved therapeutic clusters and differentiates the mechanism of action of different PI3K/mTOR, Aurora kinase and EZH2 inhibitors.
J.C.M. Uitdehaag, J.A.D.M. De Roos, M.B.W. Prinsen, N. Willemsen-Seegers, J.R.F. De Vetter, J. Dylus, A.M. Van Doornmalen, J. Kooijman, M. Sawa, S.J.C. Van Gerwen, J. De Man, R.C. Buijsman, G.J.R. Zaman
Joost C.M. Uitdehaag, Jeroen A.D.M. de Roos, Martine B.W. Prinsen, Nicole Willemsen-Seegers, Judith R.F. de Vetter, Jelle Dylus, Antoon M. van Doornmalen, Jeffrey Kooijman, Masaaki Sawa, Suzanne J.C. van Gerwen, Jos de Man, Rogier C. Buijsman, Guido J.R. Zaman