Pseudokinases are proteins that structurally resemble kinases but lack the amino acid residues essential for catalytic phosphorylation activity, rendering them enzymatically inactive. They account for approximately 10% of the entire human kinome.
Their implication in a broad spectrum of diseases underscores their potential as therapeutic targets, paving the way for innovative treatment strategies that circumvent traditional reliance on enzymatic activity.
Carna's pseudokinases are available as biotinylated proteins for versatile applications across a wide range of research and development needs.

Cat#    08-618-20C        BTN-JAK2(JH2)
Cat#    08-619-20C         BTN-TYK2(JH2)
Cat#    08-620-20C         BTN-ERBB3(HER3)
Cat#    09-403-20N         BTN-IRAK3
Cat#    09-408-20N         BTN-MLKL

Carna's Biotinylated Proteins, which are biologically labeled with a single biotin molecule at the N- or C- terminus, are useful not only for affinity measurements to evaluate interactions between molecules, but also for a wide range of other applications. Please try them out!

We’re pleased to announce the launch of our newly categorized web pages under the title: Kinase Assay Support Portal. These pages are designed to share our expertise and insights, including platform-specific support information, aimed at helping your laboratory in setting up drug evaluation and screening assays.
Please discover the valuable resources now available at Kinase Assay Support Portal

GST-tagged ALK[L1196M/D1203N] has been released.

Cat#    08-823        ALK(L1196M/D1203N)

Carna's Kinase Proteins are all produced 100% in-house and will assist your kinase drug discovery with its proven quality. For your experiments requiring immobilization of a protein such as SPR analyses, please try our Biotinylated Protein Kinases which have a single biotin attached to the N-terminus.
Our protein products will surely help reduce your efforts and increase your data quality.

We also offer custom production services. For more information, please feel free to contact us.

Biotinylated protein product, BTN-ROS(ROS1), has been released.

Cat#    08-463-20N        BTN-ROS(ROS1)

Carna's Biotinylated Protein Kinases, which are biologically labeled with a single biotin molecule at the N-terminus, are useful not only for affinity measurements to evaluate interactions between molecules, but also for a wide range of other applications incluidn activity assays. Please try them out!

• Binding Kinetics of crizotinib on ROS(ROS1)

Biotinylated protein product, BTN-ACVR1B(ALK4), has been released.

Cat#    09-435-20N        BTN-ACVR1B(ALK4)

Carna's Biotinylated Protein Kinases, which are biologically labeled with a single biotin molecule at the N-terminus, are useful not only for affinity measurements to evaluate interactions between molecules, but also for a wide range of other applications. Please try them out!

• Binding Kinetics of TAE684 on ACVR1B(ALK4)

The full-length MAP3K2 (1-619aa) GST-tagged product has been released.

Cat#    07-154    MAP3K2(FL)

Please utilize this product along with the existing catalytic domain(336-619aa) GST-tagged product Cat#07-104    MAP3K2 for your research and experimental purposes.

Carna's Kinase Proteins are all produced 100% in-house and will assist your kinase drug discovery with its proven quality. For your experiments requiring immobilization of a protein such as SPR analyses, please try our Biotinylated Protein Kinases which have a single biotin attached to the N-terminus.
Our protein products will surely help reduce your efforts and increase your data quality.

Four(4) more kinase proteins have been added to our list.

Cat#    08-821                                FGFR3(E587Q)
Cat#    08-428-20N                    BTN-EGFR(d746-750/T790M)
Cat#    01-410-20N                    BTN-ROCK2
Cat#    02-458-20N                    BTN-PRKD2(PKD2)

Carna's Kinase Proteins are all produced 100% in-house and will assist your kinase drug discovery with its proven quality. For your experiments requiring immobilization of a protein such as SPR analyses, please try our Biotinylated Protein Kinases which have a single biotin attached to the N-terminus.
Our protein products will surely help reduce your efforts and increase your data quality.

We also offer custom production services. For more information, please feel free to contact us.

Four(4) FGFR3 mutant kinase protein products (GST-tagged) have been released.

Cat#    08-818                 FGFR3(N540K)
Cat#    08-819                FGFR3(V553L)
Cat#    08-820                FGFR3(V553M)
Cat#    08-822                 FGFR3(L608V)

Carna's Kinase Proteins are all produced 100% in-house and will assist your kinase drug discovery with its proven quality. For your experiments requiring immobilization of a protein such as SPR analyses, please try our Biotinylated Protein Kinases which have a single biotin attached to the N-terminus.
Our protein products will surely help reduce your efforts and increase your data quality.

We also offer custom production services. For more information, please feel free to contact us.

Three(3) more biotinylated protein products have been released.

Cat#    08-704-20N                 BTN-BTK(A428D)
Cat#    08-706-20N                BTN-BTK(V416L)
Cat#    08-706-23N                BTN-BTK(V416L)(non-activated)

Carna's Kinase Proteins are all produced 100% in-house and will assist your kinase drug discovery with its proven quality. For your experiments requiring immobilization of a protein such as SPR analyses, please try our Biotinylated Protein Kinases which have a single biotin attached to the N-terminus.
Our protein products will surely help reduce your efforts and increase your data quality.

We also offer custom production services. For more information, please feel free to contact us.

New targets were added to our Mobility Shift Assay services!

Four(4) New targets added

CDK4/CycD1    (Km=1mM ATP)
DCAMKL1        (Km and 1mM ATP)
MAP4K5            (Km and 1mM ATP)
SIK3                    (Km and 1mM ATP)

Five(5) 1mM ATP targets added

CK1γ1
CK1γ2
CK1γ3
CK2α2/β
DCAMKL2

For the details, please check Our latest Profiling Book, As of April 18, 2025.

(Important)
For your service request, please be sure to use the latest application form downloaded from our website.
We sincerely appreciate your cooperation.

If you have any questions, please feel free to contact us.

Carnabio Sciences will close our operation from April 29(Tue) through May 6(Tue), 2025 for National holidays in Japan. Our normal business will be resumed on May 7, 2023, and all the messages received and orders placed within the holiday period will be dealt with and/or answered back right after that.
Our subsidiary in the U.S.A.and all our distributors outside of Japan will remain open business as usual.
We regret any inconveniences this might cause to our valued customers.

Three (3) more kinase proteins have been added to our list.

Cat#    08-925-20N                    BTN-FGFR2(N549K/V564F)
Cat#    08-925-23N                    BTN-FGFR2(N549K/V564F)(non-activated)
Cat#    08-815                            FGFR2(N549K/V564F)

Carna's Kinase Proteins are all produced 100% in-house and will assist your kinase drug discovery with its proven quality. For your experiments requiring immobilization of a protein such as SPR analyses, please try our Biotinylated Protein Kinases which have a single biotin attached to the N-terminus.
Our protein products will surely help reduce your efforts and increase your data quality.

We also offer custom production services. For more information, please feel free to contact us.

Starting this June, the assay schedule for the Mobility Shift Assay and ADP-Glo ​​Assay Services will change, resulting in an increased frequency of assays, making it easier for you to use our services!!

For schedule details, please check "Profiling Services Schedule after June 1, 2025" below or check the PDF schedule attached at the bottom of each assay web page.

If you have questions about this change, please contact us by info@carnabio.com

• Profiling Services Schedule after June 1, 2025

Two(2) more biotinylated protein products have been released.

Cat#    08-923-20N                BTN-FGFR2(M538L)
Cat#    08-923-23N                BTN-FGFR2(M538L)(non-activated)

Carna's Kinase Proteins are all produced 100% in-house and will assist your kinase drug discovery with its proven quality. For your experiments requiring immobilization of a protein such as SPR analyses, please try our Biotinylated Protein Kinases which have a single biotin attached to the N-terminus.
Our protein products will surely help reduce your efforts and increase your data quality.

We also offer custom production services. For more information, please feel free to contact us.

Three(3) more biotinylated protein products have been released.

Cat#    04-471-20N                 BTN-CDK10(PISSLRE)/CycQ
Cat#    08-922-20N                BTN-FGFR2(M537I)
Cat#    08-922-23N                BTN-FGFR2(M537I)(non-activated)

Carna's Kinase Proteins are all produced 100% in-house and will assist your kinase drug discovery with its proven quality. For your experiments requiring immobilization of a protein such as SPR analyses, please try our Biotinylated Protein Kinases which have a single biotin attached to the N-terminus.
Our protein products will surely help reduce your efforts and increase your data quality.

We also offer custom production services. For more information, please feel free to contact us.

Six(6) more biotinylated protein products have been released.

Cat#    01-440-20N                BTN-PKCθ(PRKCQ)
Cat#    01-440-23N                BTN-PKCθ(PRKCQ)(non-activated)
Cat#    08-924-20N                BTN-FGFR2(M537I/M538L)
Cat#    08-924-23N                BTN-FGFR2(M537I/M538L)(non-activated)
Cat#    08-926-20N                BTN-FGFR2(L617V)
Cat#    08-926-23N                BTN-FGFR2(L617V)(non-activated)

Carna's Kinase Proteins are all produced 100% in-house and will assist your kinase drug discovery with its proven quality. For your experiments requiring immobilization of a protein such as SPR analyses, please try our Biotinylated Protein Kinases which have a single biotin attached to the N-terminus.
Our protein products will surely help reduce your efforts and increase your data quality.

We also offer custom production services. For more information, please feel free to contact us.

Seven(7) more biotinylated protein products have been released.

Cat#    04-496-20N                BTN-CDK8
Cat#    04-730-20N                BTN-CDK19(CDC2L6)
Cat#    02-464-20N                BTN-TSSK1B(TSSK1)
Cat#    02-465-20N                BTN-TSSK2
Cat#    08-459-23N                BTN-RET(non-activated)
Cat#    08-927-20N                BTN-FGFR2(K659M)
Cat#    08-927-23N                BTN-FGFR2(K659M)(non-activated)

Carna's Kinase Proteins are all produced 100% in-house and will assist your kinase drug discovery with its proven quality. For your experiments requiring immobilization of a protein such as SPR analyses, please try our Biotinylated Protein Kinases which have a single biotin attached to the N-terminus.
Our protein products will surely help reduce your efforts and increase your data quality.

We also offer custom production services. For more information, please feel free to contact us.