Carna Biosciences, Inc. in Japan will be closed for the Year-end/New Year holidays from December 27, 2024 through January 5, 2025. We apologize for any inconveniences this may cause you.

Our office in the United States and all our overseas agencies will operate according to their own business schedules. Please contact your local representatives for more information.

Wishin you a wonderful holiday season and a very happy New Year！

To celebrate the launch of our MSA profiling service using Sciex BioPhase™ 8800 Capillary Electrophoresis System, we have released on our website the kinase profiling data of 60 FDA-approved kinase inhibitors performed by Carna, as well as the kinome plots that have visualized the profiling results. For more details, please visit our new page!

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Three(3) more biotinylated protein products have been released.

Cat#    08-759-20N                BTN-EGFR(T790M/C797S/L858R)
Cat#    08-910-20N                BTN-FGFR2(V564F)
Cat#    08-910-23N                BTN-FGFR2(V564F)(non-activated)

Carna's Kinase Proteins are all produced 100% in-house and will assist your kinase drug discovery with its proven quality. For your experiments requiring immobilization of a protein such as SPR analyses, please try our Biotinylated Protein Kinases which have a single biotin attached to the N-terminus.
Our protein products will surely help reduce your efforts and increase your data quality.

We also offer custom production services. For more information, please feel free to contact us.

Two (2) monomeric CDKs without regulatory subunits have been newly added to the list of biotinylated protein products.

Cat#    04-422-20N                BTN-CDK2
Cat#    04-495-20N                BTN-CDK7

Monomeric CDKs (cyclin-dependent kinases) that are not bound to regulatory subunits often exhibit little kinase activity, so they are suitable for evaluation using binding assays such as surface plasmon resonance (SPR).

Carna's Kinase Proteins are all produced 100% in-house and will assist your kinase drug discovery with its proven quality. For your experiments requiring immobilization of a protein such as SPR analyses, please try our Biotinylated Protein Kinases which have a single biotin attached to the N-terminus.
Our protein products will surely help reduce your efforts and increase your data quality.

We also offer custom production services. For more information, please feel free to contact us.

• Reference SPR Data (CDK2)
• Reference SPR Data (CDK7)

Ten(10) more kinase proteins have been added to our list.

(Biotinylated Kinases)
Cat#    04-480-20N                    BTN-CDK1(CDC2)
Cat#    04-494-20N                    BTN-CDK6
Cat#    04-481-20N                    BTN-CDK3
Cat#    04-492-20N                    BTN-CDK5/p35
Cat#    04-493-20N                    BTN-CDK5
Cat#    08-909-20N                    BTN-FGFR2(N549K)
Cat#    08-909-23N                    BTN-FGFR2(N549K)[non-activated]
Cat#    08-482-20N                    BTN-TEC
Cat#    08-482-23N                    BTN-TEC[non-activated]

（GST-tagged Kinases）
Cat#    04-174                    CDK3/CycC

Carna's Kinase Proteins are all produced 100% in-house and will assist your kinase drug discovery with its proven quality. For your experiments requiring immobilization of a protein such as SPR analyses, please try our Biotinylated Protein Kinases which have a single biotin attached to the N-terminus.
Our protein products will surely help reduce your efforts and increase your data quality.

We also offer custom production services. For more information, please feel free to contact us.

The 22nd Discovery on Target will be held from Sep.30 through Oct.4, 2024 in Boston(Sheraton Boston) and Carna will co-present with Carterra there.

Title：Fragments to Drugs: How Carterra's Ultra and CarnaBio's biotinylated kinases synergize to simplify kinase inhibitor discovery and optimization
Date & Time: Oct.1 2:35 PM EST
Session：Lead Generation Strategies

Primary presenter ：　Adam Shutes, Ph.D. Senior Scientific Consultant

Simultaniously, two(2）posters will be presented at the venue:

・The Development of a Novel Mobility Shift Analysis System for Kinase Small Molecule Drug Discovery using the SCIEX BioPhase 8800
・From fragments to Molecules to Approved Drugs: How the Carterra Ultra HT-SPR and CarnaBio's biotinylated kinome make kinase inhibitor discovery and optimization easy

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Two(2) more biotinylated protein products have been released.

Cat#    08-483-20N                BTN-TXK
Cat#    04-430-20N                BTN-DYRK1A

Carna's Kinase Proteins are all produced 100% in-house and will assist your kinase drug discovery with its proven quality. For your experiments requiring immobilization of a protein such as SPR analyses, please try our Biotinylated Protein Kinases which have a single biotin attached to the N-terminus.
Our protein products will surely help reduce your efforts and increase your data quality.

We also offer custom production services. For more information, please feel free to contact us.

Four more biotinylated protein products have been released.

Cat#    08-908-20N                BTN-FGFR2(N549D)
Cat#    08-908-23N                BTN-FGFR2(N549D)(non-activated)
Cat#    04-427-20N                BTN-CLK2
Cat#    04-429-20N                BTN-CLK4

Carna's Kinase Proteins are all produced 100% in-house and will assist your kinase drug discovery with its proven quality. For your experiments requiring immobilization of a protein such as SPR analyses, please try our Biotinylated Protein Kinases which have a single biotin attached to the N-terminus.
Our protein products will surely help reduce your efforts and increase your data quality.

We also offer custom production services. For more information, please feel free to contact us.

Carna’s Next-Gen Mobility Shift Assay (MSA) System supporting kinase drug discovery is now operational with scientific and budget friendly benefits!

            Valid Now through November 27, 2024
            Don’t miss these one-time opportunities!

Offer 1 　　　　
30% discount for reciprocal biochemical or cellular studies!

         >> Step 1: Evaluate compounds using either our biochemical or cell-based assay services.
        >> Step 2: Receive 30% discount on service order using same compounds in the reciprocal service (biochemical/cellular).

Assay services included in this offer:
Mobility Shift Assay(MSA)/IMAP™ Services & ADP-Glo™ Assay Services
and
NanoBRET™ TE Intracellular Kinase Assay Services

Offer 2
Zero Cost follow-up IC50 determinations!

        >>Step 1: Evaluate compounds in our biochemical % inhibition service.
        >>Step 2: Receive ZERO COST IC50 follow up studies using same compounds.

[Offer Conditions]
    1. With a % inhibition order against 50 or more kinase targets, receive complimentary follow-up IC50 determinations against up to 4 kinase targets* (for each screened compound).
     2. With a % inhibition order against 100 or more kinase targets, receive complimentary follow-up IC50 determinations against up to 8 kinase targets* (for each screened compound).

*The kinase targets selected for free follow-up IC50 determination studies must be those where the compound has a >50 % inhibitory effect.

Study report comes with Carna’s original Kinome Map, on which your data is graphically displayed for easy assessment of specificity and activity.

For details, please check here contact us at info@carnabio.com or get in touch with our local representatives!!

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Biotinylated FGFR2[C491A/V564L] products, with or without ATP treatment, have been added to the list.

Cat#    08-906-20N            BTN-FGFR2(C491A/V564L)
Cat#    08-906-23N            BTN-FGFR2(C491A/V564L)(non-activated)

Carna's Kinase Proteins are all produced 100% in-house and will assist your kinase drug discovery with its proven quality. For your experiments requiring immobilization of a protein such as SPR analyses, please try our Biotinylated Protein Kinases which have a single biotin attached to the N-terminus.
Our protein products will surely help reduce your efforts and increase your data quality.

We also offer custom production services. For more information, please feel free to contact us.

Five (5) more kinase proteins have been added to our list.

Cat#    04-171                  CDK10(PISSLRE)/CycQ
Cat#    07-113                  MAP4K5(KHS1)
Cat#    08-816                  FGFR2(L617V)
Cat#    08-907-20N        BTN-FGFR2(E565A)
Cat#    08-907-23N        BTN-FGFR2(E565A)(non-activated)

Carna's Kinase Proteins are all produced 100% in-house and will assist your kinase drug discovery with its proven quality. For your experiments requiring immobilization of a protein such as SPR analyses, please try our Biotinylated Protein Kinases which have a single biotin attached to the N-terminus.
Our protein products will surely help reduce your efforts and increase your data quality.

We also offer custom production services. For more information, please feel free to contact us.

Two (2) more FGFR2 mutants have been added to our list as GST-tagged products.

Cat#    08-814            FGFR2(M537I/M538L)
Cat#    08-817            FGFR2(K659M)

Carna's Kinase Proteins are all produced 100% in-house and will assist your kinase drug discovery with its proven quality. For your experiments requiring immobilization of a protein such as SPR analyses, please try our Biotinylated Protein Kinases which have a single biotin attached to the N-terminus.
Our protein products will surely help reduce your efforts and increase your data quality.

We also offer custom production services. For more information, please feel free to contact us.

Three(3) more EGFR mutants have been added to our list as GST-tagged products.

Cat#    08-801            EGFR(L718M/T790M/C797S/L858R)
Cat#    08-802            EGFR(L718Q/T790M/C797S/L858R)
Cat#    08-803            EGFR(L718V/T790M/C797S/L858R)

Carna's Kinase Proteins are all produced 100% in-house and will assist your kinase drug discovery with its proven quality. For your experiments requiring immobilization of a protein such as SPR analyses, please try our Biotinylated Protein Kinases which have a single biotin attached to the N-terminus.
Our protein products will surely help reduce your efforts and increase your data quality.

We also offer custom production services. For more information, please feel free to contact us.

Three more mutant proteins, EGFR[N771GY], FGFR2[M537I] and FGFR2[M538L], have been added to our list as GST-tagged products.

Cat#    08-110            EGFR(N771GY)
Cat#    08-812            FGFR2(M537I)
Cat#    08-813            FGFR2(M538L)

Carna's Kinase Proteins are all produced 100% in-house and will assist your kinase drug discovery with its proven quality. For your experiments requiring immobilization of a protein such as SPR analyses, please try our Biotinylated Protein Kinases which have a single biotin attached to the N-terminus.
Our protein products will surely help reduce your efforts and increase your data quality.

We also offer custom production services. For more information, please feel free to contact us.

Another EGFR mutant, EGFR[N771_P772insH] has been added to our list as a GST-tagged product.

Cat#    08-149            EGFR(N771_P772insH)

Carna's Kinase Proteins are all produced 100% in-house and will assist your kinase drug discovery with its proven quality. For your experiments requiring immobilization of a protein such as SPR analyses, please try our Biotinylated Protein Kinases which have a single biotin attached to the N-terminus.
Our protein products will surely help reduce your efforts and increase your data quality.

We also offer custom production services. For more information, please feel free to contact us.

FGFR2[V564L] biotinylated protein products, with two activation states: Activated and Non-Activated have been added to our list

Cat#    08-904-20N                BTN-FGFR2(V564L)
Cat#    08-904-23N                BTN-FGFR2(V564L)(non-activated)

Carna's Kinase Proteins are all produced 100% in-house and will assist your kinase drug discovery with its proven quality. For your experiments requiring immobilization of a protein such as SPR analyses, please try our Biotinylated Protein Kinases which have a single biotin attached to the N-terminus.
Our protein products will surely help reduce your efforts and increase your data quality.

We also offer custom production services. For more information, please feel free to contact us.

FGFR2[N549H] biotinylated protein products, with two activation states: Activated and Non-Activated have been added to our list

Cat#    08-901-20N                BTN-FGFR2(N549H)
Cat#    08-901-23N                BTN-FGFR2(N549H)(non-activated)

Carna's Kinase Proteins are all produced 100% in-house and will assist your kinase drug discovery with its proven quality. For your experiments requiring immobilization of a protein such as SPR analyses, please try our Biotinylated Protein Kinases which have a single biotin attached to the N-terminus.
Our protein products will surely help reduce your efforts and increase your data quality.

We also offer custom production services. For more information, please feel free to contact us.

Carnabio Sciences will close our operation from April 27(Sat) through May 6(Mon), 2024 for National holidays in Japan. Our normal business will be resumed on May 7, 2024, and all the messages received and orders placed within the holiday period will be dealt with and/or answered back right after that.
Our subsidiary in the U.S.A.and all our distributors outside of Japan will remain open business as usual.
We regret any inconveniences this might cause to our valued customers.

Our Profiling Book, which contains all of our biochemical assay condition details, has been revised. Please check Profiling Book of April 12, 2024 edition .

The following target conditions have been changed :

SPHK1・SPHK2　
Assay platform changed from MSA to ADP-Glo^TM.
(Following this change, preincubation service for SPHK1 has been terminated)

HPK1 (MAP4K1)・MAP4K2
In addition to ~ Km value, 1mM ATP concentration also becomes available.

Our Mobility Shift Assay experimental system is gradually transitioned from the LabChip series provided by PerkinElmer to our own proprietary system using Sciex's BioPhase 8800.
If you would like more information, please contact us from here.

Reflecting this update, all our application forms also have been updated. Please be sure to use the latest version downloaded from our website when you request our biochemical assay services.

Four more CDK protein products have been newly added to our list.

Cat#    04-176                                        CDK1(CDC2)/CycE1
Cat#    04-192                                        CDK5/p35
Cat#    04-407-20N                             BTN-CDK6/CycD3
Cat#    04-407-23N                             BTN-CDK6/CycD3(non-activated)

Carna's Kinase Proteins are all produced 100% in-house and will assist your kinase drug discovery with its proven quality. For your experiments requiring immobilization of a protein such as SPR analyses, please try our Biotinylated Protein Kinases which have a single biotin attached to the N-terminus.
Our protein products will surely help reduce your efforts and increase your data quality.

We also offer custom production services. For more information, please feel free to contact us.

FGFR2[V564I]as a biotinylated protein product with two activation states: Activated and Non-Activated, and CDK4/CycD1 as a GST-tagged product have been added to our list

Cat#    08-902-20N                BTN-FGFR2(V564I)
Cat#    08-902-23N                BTN-FGFR2(V564I)(non-activated)
Cat#    04-120                         CDK4/CycD1

Carna's Kinase Proteins are all produced 100% in-house and will assist your kinase drug discovery with its proven quality. For your experiments requiring immobilization of a protein such as SPR analyses, please try our Biotinylated Protein Kinases which have a single biotin attached to the N-terminus.
Our protein products will surely help reduce your efforts and increase your data quality.

We also offer custom production services. For more information, please feel free to contact us.

Another LTK mutant, LTK[L650F] kinase protein has been newly added to our lineup as a GST-tagged product!

Cat#    08-597                LTK(L650F)

Carna's Kinase Proteins are all produced 100% in-house and will assist your kinase drug discovery with its proven quality. For your experiments requiring immobilization of a protein such as SPR analyses, please try our Biotinylated Protein Kinases which have a single biotin attached to the N-terminus.
Our protein products will surely help reduce your efforts and increase your data quality.

We also offer custom production services. For more information, please feel free to contact us.

Three more biotinylated protein products have been released.

Cat#    08-905-23N                BTN-FGFR2(C491A/V564I)(non-activated)
Cat#    08-711-20N                BTN-EGFR(d746-750/T790M/C797S/L858R)
CAt#    08-790-20N                BTN-ALK(I1171T)

Carna's Kinase Proteins are all produced 100% in-house and will assist your kinase drug discovery with its proven quality. For your experiments requiring immobilization of a protein such as SPR analyses, please try our Biotinylated Protein Kinases which have a single biotin attached to the N-terminus.
Our protein products will surely help reduce your efforts and increase your data quality.

We also offer custom production services. For more information, please feel free to contact us.