Profiling Data ＆Kinome Plot of 60 FDA Approved Kinase Inhibitors

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Profiling Data ＆Kinome Plot of 60 FDA Approved Kinase Inhibitors

Profiling Data ＆Kinome Plot of 60 FDA Approved Kinase Inhibitors

When leveraging existing data to enhance the efficiency of drug development and reduce costs, it is crucial to rely on high-quality data to ensure reliable predictions.

Carna has profiled 60 FDA-approved kinase inhibitors using primarily our Mobility Shift Assay（MSA) platform¹⁾ and now presents the results as visualized data, using kinome plots²⁾. Our MSA provides a homogenous ratiometirc measurement of substrate and product, guaranteeing precision and reproducibility in the final readout. These data can be useful in repositioning approved molecules against other targets as tool compounds/drugs, or against other therapeutic indications, or even helping to understand observed in vivo toxicities.

1) Compound concentration: 1 μmol/L, ATP concentration: Km bin.
2) Targets not plotted on the tree indicate that the inhibition rate of the compound is <0 or it has not been tested.

Click on each plot to see an enlarged image.
You may download the excel data of these profiled 60 FDA-approved kinase inhibitors from here. Or, please contact us at info@carnabio.com for your data request.